A quantitative study of spinothalamic neurons in laminae I, III, and IV in lumbar and cervical segments of the rat spinal cord.
A quantitative study of spinothalamic neurons in laminae I, III, and IV in lumbar and cervical segments of the rat spinal cord.
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DOI：
10.1002/cne.21811
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发表时间：
2008-11-01
影响因子：
2.5
通讯作者：
Todd, Andrew J.
中科院分区：
文献类型：
--
作者：
Al-Khater, Khulood M.;Kerr, Robert;Todd, Andrew J.
浅层脊髓背角的主要上行输出包括I层中的投射神经元，以及表达神经激肽1受体（NK 1 r）并具有进入浅层树突的III-IV层中的神经元。这些群体中的每一个中的一些神经元属于脊髓丘脑束，其通过丘脑将伤害性信息传递到涉及疼痛的皮质区域。最近发现了从颈浅背角到后三角核（PoT）的投射。PoT位于丘脑的尾端，在许多以前的逆行追踪研究中未包括在注射部位。我们已经注射各种示踪剂（霍乱毒素B亚单位，荧光金，和荧光乳胶微球）到丘脑中，以估计在这两个群体中的每一个脊髓丘脑神经元的数量，并调查他们的投射目标。大多数I层和III/IV层NK 1 r免疫反应阳性脊髓丘脑神经元在颈段和腰段可以标记从注射集中在PoT。我们的研究结果表明，有90个椎板I脊髓丘脑神经元每侧在C7和15在L4，其中一些在C7只项目到PoT。我们发现，85%的第III/IV层NK 1 R免疫反应神经元在C6和17%的L5属于脊髓丘脑束，这些显然项目专门向尾侧丘脑，包括PoT。由于PoT项目的第二躯体感觉和岛叶皮层，我们的研究结果表明，这些都是这两个群体的脊髓丘脑神经元传递的信息的主要目标。
The major ascending outputs from superficial spinal dorsal horn consist of projection neurons in lamina I, together with neurons in laminae III–IV that express the neurokinin 1 receptor (NK1r) and have dendrites that enter the superficial laminae. Some neurons in each of these populations belong to the spinothalamic tract, which conveys nociceptive information via the thalamus to cortical areas involved in pain. A projection from the cervical superficial dorsal horn to the posterior triangular nucleus (PoT) has recently been identified. PoT is at the caudal end of the thalamus and was not included in injection sites in many previous retrograde tracing studies. We have injected various tracers (cholera toxin B subunit, Fluoro-Gold, and fluorescent latex microspheres) into the thalamus to estimate the number of spinothalamic neurons in each of these two populations, and to investigate their projection targets. Most lamina I and lamina III/IV NK1r-immunoreactive spinothalamic neurons in cervical and lumbar segments could be labeled from injections centered on PoT. Our results suggest that there are 90 lamina I spinothalamic neurons per side in C7 and 15 in L4 and that some of those in C7 only project to PoT. We found that 85% of the lamina III/IV NK1r-immunoreactive neurons in C6 and 17% of those in L5 belong to the spinothalamic tract, and these apparently project exclusively to the caudal thalamus, including PoT. Because PoT projects to second somatosensory and insular cortices, our results suggest that these are major targets for information conveyed by both these populations of spinothalamic neurons.
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