Influenza transmission in a cohort of households with children: 2010-2011.
Influenza transmission in a cohort of households with children: 2010-2011.
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DOI：
10.1371/journal.pone.0075339
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Monto AS
中科院分区：
文献类型：
--
作者：
Petrie JG;Ohmit SE;Cowling BJ;Johnson E;Cross RT;Malosh RE;Thompson MG;Monto AS
家庭在流感的社区传播中发挥着重要作用，是缓解战略的潜在目标。我们在2010-2011年流感季节招募并随访了328个有儿童的家庭;该季节的特征是甲型H3 N2流感、甲型H1 N1流感和B型流感病毒的传播。从患有急性呼吸道疾病的受试者中采集标本，并在实时逆转录酶聚合酶链反应（RT-PCR）测定中检测流感。流感病例分为社区获得性和家庭获得性，并估计传播参数。78个家庭（24%）被引入流感，23个家庭记录了对暴露家庭成员的传播。年轻家庭（平均年龄<22岁）和未报告家庭加湿的家庭更有可能传播，但与家庭疫苗接种覆盖率无关。继发感染风险（总体为9.7%）在幼儿（<9岁）中最高，并因流感类型/亚型而变化很大，其中甲型流感（H3 N2）风险最高。连续间隔（总体为3.2天）也因流感类型而异，B型流感最长。与成人相比，儿童症状性疾病的持续时间较短，并且流感疫苗接种状态没有差异。在一个流感季节对有儿童的家庭进行的前瞻性研究发现，不同流感类型/亚型、受试者年龄和家庭湿度的家庭传播存在差异，这提示了减少传播的干预措施的可能目标。
Households play a major role in community spread of influenza and are potential targets for mitigation strategies. We enrolled and followed 328 households with children during the 2010-2011 influenza season; this season was characterized by circulation of influenza A (H3N2), A (H1N1)pdm09 and type B viruses. Specimens were collected from subjects with acute respiratory illnesses and tested for influenza in real-time reverse transcriptase polymerase chain reaction (RT-PCR) assays. Influenza cases were classified as community-acquired or household-acquired, and transmission parameters estimated. Influenza was introduced to 78 (24%) households and transmission to exposed household members was documented in 23 households. Transmission was more likely in younger households (mean age <22 years) and those not reporting home humidification, but was not associated with household vaccination coverage. The secondary infection risk (overall 9.7%) was highest among young children (<9 years) and varied substantially by influenza type/subtype with the highest risk for influenza A (H3N2). The serial interval (overall 3.2 days) also varied by influenza type and was longest for influenza B. Duration of symptomatic illness was shorter in children compared with adults, and did not differ by influenza vaccination status. Prospective study of households with children over a single influenza season identified differences in household transmission by influenza type/subtype, subject age, and home humidification, suggesting possible targets for interventions to reduce transmission.
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病毒检测及其与流感样性疾病期间的症状相关联，在接受随机对照疫苗试验的健康成年人样本中。
影响因子：
4.4
作者：
Howard PF;McCaw JM;Richmond PC;Nissen M;Sloots T;Lambert SB;Lai M;Greenberg M;Nolan T;McVernon J
通讯作者：
McVernon J
影响因子：
11.8
作者：
Ohmit, Suzanne E.;Monto, Arnold S.
通讯作者：
Monto, Arnold S.
DOI：
10.1073/pnas.0706849105
发表时间：
2008-03-25
影响因子：
11.1
作者：
Halloran, M. Elizabeth;Ferguson, Neil M.;Cooley, Philip
通讯作者：
Cooley, Philip
影响因子：
2
作者：
Cauchemez, S;Carrat, F;Boëlle, PY
通讯作者：
Boëlle, PY
影响因子：
11.8
作者：
Papenburg, Jesse;Baz, Mariana;Boivin, Guy
通讯作者：
Boivin, Guy