Design of a two-dimensional interplanar heterojunction for catalytic cancer therapy.
Design of a two-dimensional interplanar heterojunction for catalytic cancer therapy.
复制标题
用于催化癌症治疗的二维平面异质结的设计。
DOI：
10.1038/s41467-022-30166-1
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发表时间：
2022-05-03
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
有限的底物含量是抑制催化疗法的抗肿瘤作用的主要障碍。在此，制备了在超声辐照下产生·OH的二维面间异质结（FeOCl/FeOOH NS），并将其用于催化癌症治疗。这种面间异质结是通过用羟基取代氯氧化铁中的氯来制备的。得益于较长的羟基键长和增强的与水的亲和力，碱置换处理在一个步骤中集成了面间异质结合成和剥离。特别地，由于费米能级的对准，形成了内建电场促进的Z型面间异质结。FeOCl价带上的空穴具有很强的催化H2O析O2的能力，同时生成的O2被FeOOH导电带上的电子直接还原为H2 O2。FeOCl/FeOOH NS自供H2 O2的能力保证了FeOCl/FeOOH NS催化的类Fenton反应有效生成·OH，表现出优异的抗肿瘤性能。化学动力学疗法依赖于芬顿或类芬顿反应在肿瘤区域产生羟基自由基。在这里，作者设计了一个二维平面间异质结，在超声辐射下原位产生羟基自由基，在临床前模型中显示抗癌活性。
Limited substrates content is a major hurdle dampening the antitumor effect of catalytic therapy. Herein, a two-dimensional interplanar heterojunction (FeOCl/FeOOH NSs) with ·OH generation under ultrasound irradiation is fabricated and utilized for catalytic cancer therapy. This interplanar heterojunction is prepared through replacing chlorine from iron oxychloride with hydroxyl. Benefiting from the longer hydroxyl bond length and enhanced affinity with water, the alkali replacement treatment integrates interplanar heterojunction synthesis and exfoliation in one step. In particular, a build-in electric field facilitated Z-scheme interplanar heterojunction is formed due to the aligning Fermi levels. The holes on the valence band of FeOCl have great ability to catalyze O2 evolution from H2O, meanwhile, the generated O2 is immediately and directly reduced to H2O2 by the electrons on the conductive band of FeOOH. The self-supplying H2O2 ability guarantees efficient ·OH generation via the Fenton-like reaction catalyzed by FeOCl/FeOOH NSs, which exhibits excellent anti-tumor performance. Chemodynamic therapy relies on Fenton or Fenton-like reactions to produce hydroxyl radical in the tumor region. Here the authors design a two-dimensional interplanar heterojunction with in situ hydroxyl radical generation under ultrasound irradiation, showing anti-cancer activity in preclinical models.
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