Tumor-selective catalytic nanomedicine by nanocatalyst delivery.
Tumor-selective catalytic nanomedicine by nanocatalyst delivery.
复制标题
通过纳米催化剂递送，肿瘤选择性催化纳米医学。
DOI：
10.1038/s41467-017-00424-8
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发表时间：
2017-08-25
影响因子：
16.6
通讯作者：
Shi J
中科院分区：
文献类型：
--
作者：
Huo M;Wang L;Chen Y;Shi J
与大多数正常组织细胞相比，肿瘤细胞的代谢途径不同。由此产生的肿瘤微环境将为选择性肿瘤治疗提供特有的物理化学条件。在这里，我们介绍了序贯催化纳米药物的概念，通过设计并将生物相容的纳米催化剂输送到肿瘤部位，从而有效地治疗肿瘤。将天然葡萄糖氧化酶(GOD，酶催化剂)和超小的Fe3O4纳米粒子(无机纳米酶，Fenton反应催化剂)集成到大孔可生物降解的树枝状二氧化硅纳米粒子中，制备了连续纳米催化剂。顺序式纳米催化剂中的GOD可以有效地耗尽肿瘤细胞中的葡萄糖，同时在弱酸性的肿瘤微环境中产生大量的过氧化氢，用于后续的Fe3O4纳米粒子催化的Fenton样反应。通过这些顺序的催化反应产生剧毒的羟基自由基，从而触发肿瘤细胞的凋亡和死亡。目前的工作表明，通过同时接近肿瘤治疗的选择性和效率，催化纳米药物的概念得到了证明。癌细胞的特定新陈代谢可能允许选择性的肿瘤治疗。在这里，作者展示了一种酶和负载在树枝状二氧化硅上的铁纳米颗粒的适当组合，在依赖葡萄糖和弱酸性的微环境中诱导癌细胞凋亡。
Tumor cells metabolize in distinct pathways compared with most normal tissue cells. The resulting tumor microenvironment would provide characteristic physiochemical conditions for selective tumor modalities. Here we introduce a concept of sequential catalytic nanomedicine for efficient tumor therapy by designing and delivering biocompatible nanocatalysts into tumor sites. Natural glucose oxidase (GOD, enzyme catalyst) and ultrasmall Fe3O4 nanoparticles (inorganic nanozyme, Fenton reaction catalyst) have been integrated into the large pore-sized and biodegradable dendritic silica nanoparticles to fabricate the sequential nanocatalyst. GOD in sequential nanocatalyst could effectively deplete glucose in tumor cells, and meanwhile produce a considerable amount of H2O2 for subsequent Fenton-like reaction catalyzed by Fe3O4 nanoparticles in response to mild acidic tumor microenvironment. Highly toxic hydroxyl radicals are generated through these sequential catalytic reactions to trigger the apoptosis and death of tumor cells. The current work manifests a proof of concept of catalytic nanomedicine by approaching selectivity and efficiency concurrently for tumor therapeutics. The specific metabolism of cancer cells may allow for selective tumor therapeutics. Here, the authors show that a suitable combination of an enzyme and iron nanoparticles loaded on dendritic silica induces apoptosis of cancer cells in response to the glucose-reliant and mild acidic microenvironment.
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影响因子：
29.4
作者：
Chen, Yu;Ye, Delai;Wang, Lianzhou
通讯作者：
Wang, Lianzhou
透明质酸酶增强基于纳米颗粒的光动力肿瘤治疗
影响因子：
10.8
作者：
Gong, Hua;Chao, Yu;Liu, Zhuang
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Liu, Zhuang
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影响因子：
17.1
作者：
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通讯作者：
Gu, Ning
影响因子：
10.8
作者：
Nascimento RA;Özel RE;Mak WH;Mulato M;Singaram B;Pourmand N
通讯作者：
Pourmand N
影响因子：
64.5
作者：
Hsu, Peggy P.;Sabatini, David M.
通讯作者：
Sabatini, David M.