Associations between endogenous sex hormones and FGF-23 among women and men in the Multi-Ethnic Study of Atherosclerosis.
Associations between endogenous sex hormones and FGF-23 among women and men in the Multi-Ethnic Study of Atherosclerosis.
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DOI：
10.1371/journal.pone.0268759
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
睾酮和成纤维细胞生长因子23（FGF-23）水平升高均与心血管疾病（CVD）风险升高独立相关。然而，性激素和FGF-23之间的关系还没有很好地建立。我们探讨了梅萨中老年男性和女性性激素和FGF-23之间的关联。我们研究了3，052名男性和2，868名绝经后女性，在入组时无CVD，基线血清性激素[总睾酮（T），游离T，雌二醇（E2）和性激素结合球蛋白（SHBG）]和完整的FGF-23。在性别分层分析中，我们使用多元线性回归分析了对数转换的性激素（每1 SD）和对数转换的FGF-23之间的横断面相关性，该回归分析针对社会人口统计学、CVD风险因素、估计的肾小球滤过率和矿物质代谢产物（25-羟基维生素D、钙、磷和甲状旁腺激素）进行了调整。研究参与者的平均（SD）年龄为64（10）岁。女性和男性的FGF-23中位数（IQR）相似[38（30-46）vs 38（31-47）pg/mL]。在校正分析中，在女性中，游离T增加1个SD与FGF-23增加3%相关，而SHBG与FGF-23降低2%相关。在男性中，E2增加1 SD与FGF-23升高6%相关，而总T/E2比值与FGF-23降低7%相关。总之，该探索性分析发现，女性中更具雄性激素性的性激素与FGF-23直接相关，而男性中与FGF-23呈负相关。需要进行纵向研究以确定FGF-23是否介导性激素和CVD风险之间的关系。
Elevated levels of testosterone and fibroblast growth factor 23 (FGF-23) are both independently associated with a higher risk of cardiovascular disease (CVD). However, the relationship between sex hormones and FGF-23 is not well established. We explored the association between sex hormones and FGF-23 among middle-aged to older men and women in MESA. We studied 3,052 men and 2,868 postmenopausal women free of CVD at the time of enrollment with baseline serum sex hormones [total testosterone (T), free T, estradiol (E2) and sex hormone binding globulin (SHBG)] and intact FGF-23. In sex-stratified analyses, we examined the cross-sectional associations between log-transformed sex hormones (per 1 SD) and log-transformed FGF-23 using multiple linear regression adjusted for socio-demographics, CVD risk factors, estimated glomerular filtration rate and mineral metabolites (25-hydroxyvitamin D, calcium, phosphorus and parathyroid hormone). The mean (SD) age of study participants was 64 (10) years. The median (IQR) of FGF-23 was similar in women and men [38 (30–46) vs 38 (31–47) pg/mL]. In adjusted analyses, among women, 1 SD increment in free T was associated with 3% higher FGF-23 while SHBG was associated with 2% lower FGF-23. In men, 1 SD increment in E2 was associated with 6% higher FGF-23 whereas total T/E2 ratio was associated with 7% lower FGF-23. In conclusion, this exploratory analysis found that a more androgenic sex hormone profile was directly associated with FGF-23 in women and inversely associated with FGF-23 in men. Longitudinal studies are required to determine whether FGF-23 mediates the relationship between sex hormones and CVD risk.
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DOI：
10.1152/ajpgi.00243.2005
发表时间：
2005-12-01
影响因子：
4.5
作者：
Kolek, OI;Hines, ER;Ghishan, FK
通讯作者：
Ghishan, FK
影响因子：
2.7
作者：
Hackbarth, Jennifer S.;Hoyne, Jonathan B.;Singh, Ravinder J.
通讯作者：
Singh, Ravinder J.
影响因子：
5
作者：
CAULEY, JA;GUTAI, JP;POWELL, JG
通讯作者：
POWELL, JG
影响因子：
24
作者：
Ix, Joachim H.;Katz, Ronit;Kestenbaum, Bryan R.;de Boer, Ian H.;Chonchol, Michel;Mukamal, Kenneth J.;Rifkin, Dena;Siscovick, David S.;Sarnak, Mark J.;Shlipak, Michael G.
通讯作者：
Shlipak, Michael G.
影响因子：
37.8
作者：
Mathew JS;Sachs MC;Katz R;Patton KK;Heckbert SR;Hoofnagle AN;Alonso A;Chonchol M;Deo R;Ix JH;Siscovick DS;Kestenbaum B;de Boer IH
通讯作者：
de Boer IH