Vulnerability of welders to manganese exposure--a neuroimaging study.
Vulnerability of welders to manganese exposure--a neuroimaging study.
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DOI：
10.1016/j.neuro.2014.03.007
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发表时间：
2014-12
期刊：
影响因子：
3.4
通讯作者：
Ulrike, Dydak
中科院分区：
文献类型：
--
作者：
Long Zaiyang;Jiang Yue-Ming;Li Xiang-Rong;William, Fadel;Xu Jun;Yeh Chien-Lin;Long Li-Ling;Luo Hai-Lan;Jaroslaw, Harezlak;James, Murdoch;Zheng Wei;Ulrike, Dydak
关键词：
已知锰（Mn）暴露增加会导致认知、精神和运动缺陷。锰暴露发生在不同的职业环境中，空气中的锰水平和可吸入颗粒物的大小可能有很大差异。最近的重要性，大脑皮层中的锰毒性的作用已被强调，特别是在锰诱导的神经心理学的影响。在这项研究中，我们使用磁共振成像（MRI）使用T1信号强度指数评估大脑锰累积，并使用T2* 对比度检查大脑铁含量的变化，以及磁共振光谱（MRS）测量暴露诱导的代谢物变化锰暴露焊工的皮质和脑深部区域，锰暴露的冶炼厂工人和对照工厂工人没有可测量的锰暴露。MRS数据以及T1信号强度指数和T2* 值从额叶皮质、后扣带回皮质、海马和丘脑获得。冶炼工人暴露于较高的空气锰水平，并有较长的曝光时间，这是反映在较高的锰水平，在红细胞和尿液中比焊工。尽管如此，焊工与对照组相比，比冶炼厂工人有更显著的代谢差异，特别是在额叶皮层。在两个锰暴露组中均观察到苍白球T1高信号，但只有焊工表现出明显较高的丘脑和海马T1高信号，以及额叶皮质T2* 值显著降低。我们的研究结果表明，（1）大脑皮层，特别是额叶皮层，明显参与锰神经毒性效应和（2）尽管较低的空气锰水平和较短的暴露时间，焊工表现出更广泛的神经影像学变化相比，控制比冶炼，包括可测量的沉积锰在更多的大脑区域。这些结果表明，暴露的类型（颗粒大小，灰尘与烟雾）和暴露途径发挥了重要作用，锰引起的毒性作用的程度对大脑。
Increased manganese (Mn) exposure is known to cause cognitive, psychiatric and motor deficits. Mn exposure occurs in different occupational settings, where the airborne Mn level and the size of respirable particulates may vary considerably. Recently the importance of the role of the cerebral cortex in Mn toxicity has been highlighted, especially in Mn-induced neuropsychological effects. In this study we used magnetic resonance imaging (MRI) to evaluate brain Mn accumulation using T1 signal intensity indices and to examine changes in brain iron content using T2* contrast, as well as magnetic resonance spectroscopy (MRS) to measure exposure-induced metabolite changes non-invasively in cortical and deep brain regions in Mn-exposed welders, Mn-exposed smelter workers and control factory workers with no measurable exposure to Mn. MRS data as well as T1 signal intensity indices and T2* values were acquired from the frontal cortex, posterior cingulate cortex, hippocampus, and thalamus. Smelters were exposed to higher air Mn levels and had a longer duration of exposure, which was reflected in higher Mn levels in erythrocytes and urine than in welders. Nonetheless, welders had more significant metabolic differences compared to controls than did the smelter workers, especially in the frontal cortex. T1 hyperintensities in the globus pallidus were observed in both Mn-exposed groups, but only welders showed significantly higher thalamic and hippocampal T1 hyperintensities, as well as significantly reduced T2* values in the frontal cortex. Our results indicate that (1) the cerebral cortex, in particular the frontal cortex, is clearly involved in Mn neurotoxic effects and (2) in spite of the lower air Mn levels and shorter duration of exposure, welders exhibit more extensive neuroimaging changes compared to controls than smelters, including measurable deposition of Mn in more brain areas. These results indicate that the type of exposure (particulate sizes, dust versus fume) and route of exposure play an important role in the extent of Mn-induced toxic effects on the brain.
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影响因子：
3.8
作者：
Dorman, David C.;Struve, Melanie F.;Robertson, Ian D.
通讯作者：
Robertson, Ian D.
影响因子：
2.9
作者：
Bock, Nicholas A.;Paiva, Fernando F.;Silva, Afonso C.
通讯作者：
Silva, Afonso C.
DOI：
10.3390/ijerph7072978
发表时间：
2010-07
影响因子：
--
作者：
Balkhyour MA;Goknil MK
通讯作者：
Goknil MK
影响因子：
4.9
作者：
Criswell SR;Perlmutter JS;Huang JL;Golchin N;Flores HP;Hobson A;Aschner M;Erikson KM;Checkoway H;Racette BA
通讯作者：
Racette BA
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y