CircMAN1A2 is upregulated by Helicobacter pylori and promotes development of gastric cancer.
CircMAN1A2 is upregulated by Helicobacter pylori and promotes development of gastric cancer.
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CircMAN1A2被幽门螺杆菌上调并促进胃癌的发展
DOI：
10.1038/s41419-022-04811-y
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发表时间：
2022-04-28
影响因子：
9
通讯作者：
Li, Wenjuan
中科院分区：
文献类型：
--
作者：
Guo, Ruiting;Cui, Xixi;Li, Xue;Zang, Wen;Chang, Mingjie;Sun, Zenghui;Liu, Zhifang;Sun, Yundong;Jia, Jihui;Li, Wenjuan
幽门螺杆菌（H.幽门螺杆菌）是导致胃癌的主要原因之一。据报道，circRNA在多种类型癌症的发展中起着至关重要的作用。然而，H.幽门螺杆菌诱导的circRNA在胃癌发展中的作用尚未研究。在本研究中，我们发现H. pylori可诱导AGS和BGC 823细胞中circMAN 1A 2的表达上调，而不依赖于CagA。circMAN 1A 2的下调可抑制胃癌细胞的增殖、迁移和侵袭，并且circMAN 1A 2可促进H. pylori中通过海绵状miR-1236- 3 p来调节MTA 2表达。此外，circMAN 1A 2敲低抑制体内异种移植肿瘤生长，并且circMAN 1A 2的过表达与胃癌的进展相关。因此，幽门螺杆菌可诱导circMAN 1A 2的表达，从而促进胃癌的发生发展，circMAN 1A 2可能成为胃癌新的诊断标志物和治疗靶点。
Helicobacter pylori (H. pylori) is one of the main causes of gastric cancer. It has been reported that circRNAs play a vital role in the development of multiple types of cancer. However, the role of H. pylori-induced circRNAs in the development of gastric cancer has not been studied. In this study, we found that H. pylori could induce the upregulation of circMAN1A2 in AGS and BGC823 cells independent of CagA. The downregulation of circMAN1A2 could inhibit the proliferation, migration and invasion of gastric cancer cells, and circMAN1A2 could promote the progression of gastric cancer induced by H. pylori by sponging miR-1236-3p to regulate MTA2 expression. Furthermore, circMAN1A2 knockdown inhibited xenograft tumour growth in vivo, and the overexpression of circMAN1A2 was associated with the progression of gastric cancer. Hence, Helicobacter pylori induced circMAN1A2 expression to promote the carcinogenesis of gastric cancer, and circMAN1A2 might be a new potential diagnostic marker and therapeutic target for gastric cancer.
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circMAN1A2可以作为恶性肿瘤的新型血清生物标志物
影响因子：
5.7
作者：
Fan, Chun-Mei;Wang, Jin-Peng;Zeng, Zhao-Yang
通讯作者：
Zeng, Zhao-Yang
幽门螺杆菌CagA通过触发致癌YAP通路促进胃癌发生中的上皮间质转化
DOI：
10.1186/s13046-018-0962-5
发表时间：
2018-11-22
期刊：
Journal of experimental & clinical cancer research : CR
影响因子：
--
作者：
Li N;Feng Y;Hu Y;He C;Xie C;Ouyang Y;Artim SC;Huang D;Zhu Y;Luo Z;Ge Z;Lu N
通讯作者：
Lu N
DOI：
10.1007/s11938-018-0203-1
发表时间：
2018-12
期刊：
Current treatment options in gastroenterology
影响因子：
--
作者：
Song M;Rabkin CS;Camargo MC
通讯作者：
Camargo MC
影响因子：
46.9
作者：
Jeck, William R.;Sharpless, Norman E.
通讯作者：
Sharpless, Norman E.
影响因子：
4.8
作者：
COCQUERELLE, C;MASCREZ, B;BAILLEUL, B
通讯作者：
BAILLEUL, B