Different Effects of Sleep Deprivation and Torpor on EEG Slow-Wave Characteristics in Djungarian Hamsters
Different Effects of Sleep Deprivation and Torpor on EEG Slow-Wave Characteristics in Djungarian Hamsters
复制标题
睡眠剥夺和麻木对正加仓鼠脑电图慢波特征的不同影响
作者：
V. Vyazovskiy;S. Palchykova;Peter Achermann;I. Tobler;T. Deboer
摘要先前在Djungarian仓鼠中已经表明，在每日麻木发作后的非快速眼动（NREM）睡眠中，初始脑电图（EEG）慢波活动（0.5 - 4.0 Hz频带的功率; SWA）持续增强，类似于睡眠剥夺（SD）后的SWA增加。然而，目前尚不清楚迟钝和SD后SWA增加的网络机制是否相似。睡眠期间记录在新皮层中的EEG慢波反映了大型神经元群体之间的活动和沉默期间之间的同步转换。因此，我们着手调查的特点，个别皮层脑电图慢波记录在NREM睡眠4小时SD后，在睡眠中出现后，从一个情节的日常麻木成年雄性Djungarian仓鼠。我们发现，在SD和麻痹后的第一个小时内，SWA的增加与慢波发生率和振幅的增加有关。然而，单慢波的斜率在NREM睡眠后的第一个小时，SD，但不是在麻木后，和SD后的睡眠相反，麻木后斜率的变化幅度与SWA的变化无关。此外，在SD后的前2小时内，慢波斜率逐渐降低，而在麻痹后的前2小时内，慢波斜率明显逐渐增加。数据表明，长时间的清醒和麻木对慢波特征下的皮层网络活动具有不同的影响，同时导致SWA的类似稳态睡眠反应。我们认为睡眠在清醒和麻木后的网络稳态中起着重要的作用，这与两种状态的恢复功能一致。
Abstract It has been shown previously in Djungarian hamsters that the initial electroencephalography (EEG) slow‐wave activity (power in the 0.5‐4.0 Hz band; SWA) in non‐rapid eye movement (NREM) sleep following an episode of daily torpor is consistently enhanced, similar to the SWA increase after sleep deprivation (SD). However, it is unknown whether the network mechanisms underlying the SWA increase after torpor and SD are similar. EEG slow waves recorded in the neocortex during sleep reflect synchronized transitions between periods of activity and silence among large neuronal populations. We therefore set out to investigate characteristics of individual cortical EEG slow waves recorded during NREM sleep after 4 h SD and during sleep after emergence from an episode of daily torpor in adult male Djungarian hamsters. We found that during the first hour after both SD and torpor, the SWA increase was associated with an increase in slow‐wave incidence and amplitude. However, the slopes of single slow waves during NREM sleep were steeper in the first hour after SD but not after torpor, and, in contrast to sleep after SD, the magnitude of change in slopes after torpor was unrelated to the changes in SWA. Furthermore, slow‐wave slopes decreased progressively within the first 2 h after SD, while a progressive increase in slow‐wave slopes was apparent during the first 2 h after torpor. The data suggest that prolonged waking and torpor have different effects on cortical network activity underlying slow‐wave characteristics, while resulting in a similar homeostatic sleep response of SWA. We suggest that sleep plays an important role in network homeostasis after both waking and torpor, consistent with a recovery function for both states.
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冬眠动物的慢波活动正在消失。
DOI：
--
发表时间：
1998
期刊：
Sleep research online [electronic resource] : SRO.
影响因子：
--
作者：
Larkin,JE;Heller,CH
通讯作者：
Heller,CH
影响因子：
4.6
作者：
Mackiewicz, Miroslaw;Shockley, Keith R.;Pack, Allan I.
通讯作者：
Pack, Allan I.
影响因子：
5.6
作者：
Riedner, Brady A.;Vyazovskiy, Vladyslav V.;Tononi, Giulio
通讯作者：
Tononi, Giulio
影响因子：
5.6
作者：
Vyazovskiy, Vladyslav V.;Riedner, Brady A.;Tononi, Giulio
通讯作者：
Tononi, Giulio