New Insight of Circular RNAs' Roles in Central Nervous System Post-Traumatic Injury.
New Insight of Circular RNAs' Roles in Central Nervous System Post-Traumatic Injury.
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环状RNA在创伤后中枢神经系统中作用的新认识。
DOI：
10.3389/fnins.2021.644239
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发表时间：
2021
影响因子：
4.3
通讯作者：
Wang LL
中科院分区：
文献类型：
--
作者：
Xu L;Ye X;Zhong J;Chen YY;Wang LL
中枢神经系统（CNS）创伤后损伤可导致严重的神经损伤，具有毁灭性的后果。然而，其病理生理机制仍然模糊。仍然迫切需要更有效的治疗方法。环状RNA（circRNA）是可以形成共价闭合的RNA环的非编码RNA。通过第二代测序技术、微阵列分析、生物信息学等技术，近年来的研究表明，许多circRNA在创伤性脑损伤（TBI）或脊髓损伤（SCI）后差异表达。这些circRNA在CNS创伤后损伤的增殖、炎症和凋亡中起重要作用。本文综述了近年来有关circRNA在中枢神经系统中的表达、功能以及circRNA-miRNA-mRNA相互作用网络的研究进展。还讨论了circRNA作为治疗靶点的潜在临床价值。
The central nervous system (CNS) post-traumatic injury can cause severe nerve damage with devastating consequences. However, its pathophysiological mechanisms remain vague. There is still an urgent need for more effective treatments. Circular RNAs (circRNAs) are non-coding RNAs that can form covalently closed RNA circles. Through second-generation sequencing technology, microarray analysis, bioinformatics, and other technologies, recent studies have shown that a number of circRNAs are differentially expressed after traumatic brain injury (TBI) or spinal cord injury (SCI). These circRNAs play important roles in the proliferation, inflammation, and apoptosis in CNS post-traumatic injury. In this review, we summarize the expression and functions of circRNAs in CNS in recent studies, as well as the circRNA–miRNA–mRNA interaction networks. The potential clinical value of circRNAs as a therapeutic target is also discussed.
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