Intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury.
Intestinal microbiota and melatonin in the treatment of secondary injury and complications after spinal cord injury.
复制标题
肠道菌群和褪黑激素治疗脊髓损伤后继发性损伤和并发症
DOI：
10.3389/fnins.2022.981772
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发表时间：
2022
影响因子：
4.3
通讯作者：
Yu, Yang
中科院分区：
文献类型：
--
作者：
Zhang, Yiwen;Lang, Rui;Guo, Shunyu;Luo, Xiaoqin;Li, Huiting;Liu, Cencen;Dong, Wei;Bao, Changshun;Yu, Yang
关键词：
脊髓损伤(SCI)是一种中枢神经系统(CNS)疾病，可导致损伤平面以下的感觉和运动障碍。目前，脊髓损伤的治疗方案主要集中在继发性损伤和并发症。最近的研究表明，脊髓损伤会导致肠道微生物区系的失衡，这种失衡也与脊髓损伤后的并发症有关，可能是通过微生物-脑-肠轴。褪黑激素在身体的许多部位分泌，包括松果腺和肠道，有效地保护脊髓免受二次损伤。褪黑激素的分泌受到昼夜节律的影响，也就是所谓的暗光周期，而脊髓损伤也会导致褪黑激素分泌的失调。此外，褪黑素与肠道微生物区系关系密切，通过其抗氧化和抗炎作用保护肠道屏障功能，并通过影响肠道微生物区系的代谢来增加肠道微生物区系的丰度。此外，肠道微生物区系可以通过调节色氨酸和5-羟色胺代谢来影响褪黑素的形成。本文就近年来有关肠道微生物区系、褪黑素与脊髓损伤之间关系的认识进行综述，以期为脊髓损伤治疗的临床研究提供新的理论和思路。
Spinal cord injury (SCI) is a central nervous system (CNS) disease that can cause sensory and motor impairment below the level of injury. Currently, the treatment scheme for SCI mainly focuses on secondary injury and complications. Recent studies have shown that SCI leads to an imbalance of intestinal microbiota and the imbalance is also associated with complications after SCI, possibly through the microbial-brain-gut axis. Melatonin is secreted in many parts of the body including pineal gland and gut, effectively protecting the spinal cord from secondary damage. The secretion of melatonin is affected by circadian rhythms, known as the dark light cycle, and SCI would also cause dysregulation of melatonin secretion. In addition, melatonin is closely related to the intestinal microbiota, which protects the barrier function of the gut through its antioxidant and anti-inflammatory effects, and increases the abundance of intestinal microbiota by influencing the metabolism of the intestinal microbiota. Furthermore, the intestinal microbiota can influence melatonin formation by regulating tryptophan and serotonin metabolism. This paper summarizes and reviews the knowledge on the relationship among intestinal microbiota, melatonin, and SCI in recent years, to provide new theories and ideas for clinical research related to SCI treatment.
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影响因子：
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作者：
Chang CC;Huang TY;Chen HY;Huang TC;Lin LC;Chang YJ;Hsia SM
通讯作者：
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影响因子：
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作者：
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