Electrostatic wrapping of doxorubicin with curdlan to construct an efficient pH-responsive drug delivery system
Electrostatic wrapping of doxorubicin with curdlan to construct an efficient pH-responsive drug delivery system
复制标题
静电包裹阿霉素与凝胶多糖构建高效 pH 响应药物递送系统
DOI：
10.1088/1361-6528/aa75b5
复制
发表时间：
2017-06
期刊：
影响因子：
3.5
通讯作者：
Wang Yu-Zhong
中科院分区：
文献类型：
--
作者：
Zhou Jiang-Ling;Song Fei;Tian Jia-Feng;Nie Wu-Cheng;Wang Xiu-Li;Wang Yu-Zhong
The development of environmentally responsive drug delivery systems for the treatment of cancer has attracted particular interest in recent years. However, the enhancement of drug loading capacity and realization of pH-responsive drug delivery remain challenging. Herein, we employ carboxymethyl curdlan as a hydrophilic carrier to wrap doxorubicin (DOX) directly via electrostatic interaction. The sizes of the formed nanoparticles can be simply tuned by changing their feeding ratios. In particular, the nanoparticles are highly stable in aqueous solution without size variation. In vitro drug release and cytotoxicity assays illustrate that this delivery system can release DOX differentially under various environmental conditions and transport it into cell nuclei efficiently, with comparable therapeutic effect to the free drug. These results suggest that the carrying of antitumor drugs by polysaccharide via electrostatic interaction is a simple but effective way to construct a pH-dependent drug delivery platform.
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影响因子：
46.2
作者：
Karimi M;Ghasemi A;Sahandi Zangabad P;Rahighi R;Moosavi Basri SM;Mirshekari H;Amiri M;Shafaei Pishabad Z;Aslani A;Bozorgomid M;Ghosh D;Beyzavi A;Vaseghi A;Aref AR;Haghani L;Bahrami S;Hamblin MR
通讯作者：
Hamblin MR
DOI：
10.1016/j.colsurfb.2013.09.005
发表时间：
2014
期刊：
Colloids and surfaces. B, Biointerfaces
影响因子：
--
作者：
C. Pilapong;Y. Keereeta;Samlee Munkhetkorn;S. Thongtem;T. Thongtem
通讯作者：
C. Pilapong;Y. Keereeta;Samlee Munkhetkorn;S. Thongtem;T. Thongtem
影响因子：
1.6
作者：
K. Ogawa;J. Tsurugi;Takehiko Watanabe
通讯作者：
K. Ogawa;J. Tsurugi;Takehiko Watanabe
影响因子：
3.2
作者：
L. Liên;T. Shiraki;A. Dawn;Youichi Tsuchiya;D. Tokunaga;S. Tamaru;N. Enomoto;J. Hojo;S. Shinkai
通讯作者：
L. Liên;T. Shiraki;A. Dawn;Youichi Tsuchiya;D. Tokunaga;S. Tamaru;N. Enomoto;J. Hojo;S. Shinkai
影响因子：
3.4
作者：
Posocco B;Dreussi E;de Santa J;Toffoli G;Abrami M;Musiani F;Grassi M;Farra R;Tonon F;Grassi G;Dapas B
通讯作者：
Dapas B