Pre-existing disease: the most important factor for health related quality of life long-term after critical illness: a prospective, longitudinal, multicentre trial.
Pre-existing disease: the most important factor for health related quality of life long-term after critical illness: a prospective, longitudinal, multicentre trial.
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DOI：
10.1186/cc8967
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Sjöberg F
中科院分区：
文献类型：
--
作者：
Orwelius L;Nordlund A;Nordlund P;Simonsson E;Bäckman C;Samuelsson A;Sjöberg F
本多中心研究的目的是评估危重病患者的长期（36个月）健康相关生活质量，将 ICU 幸存者的健康相关生活质量与普通人群进行比较，并检查原有疾病和与 ICU 护理相关的因素对健康相关生活质量的影响。在瑞典一所大学和两所综合医院的三个内科和外科联合重症监护病房进行的前瞻性、纵向、多中心试验。通过邮寄问卷，使用 EQ-5D 和 SF-36 评估入住 ICU 后 6、12、24 和 36 个月的健康相关生活质量，并收集 6 个月时的既存疾病信息。 ICU相关因素从当地ICU数据库中获取。在参考组中检查了合并症和健康相关的生活质量（EQ-5D；SF-36）。在入院的 5306 名患者中，有 1663 名患者被认为符合条件（在重症监护病房呆了 >24 小时，年龄≥18 岁，出院后 6 个月还活着）。在 6 个月的测量中，980 名 (59%) 患者回答了问卷。其中 739 人 (75%) 也在 12 个月时回答，595 人 (61%) 在 24 个月时回答，478 人 (47%) 在 36 个月时回答。作为参考组，使用来自医院接收区域的随机样本（n = 6093），对并发疾病进行评估和调整。入住 ICU 后 36 个月内，与健康相关的生活质量仅出现微小改善。 ICU 护理后健康相关生活质量的下降大部分与原有疾病对健康相关生活质量的影响有关。任何 ICU 相关因素对长期健康相关生活质量均没有明显影响。入住 ICU 后健康相关生活质量的下降很大一部分可归因于先前存在的疾病。 ICU 治疗后健康相关生活质量的小幅长期增量进一步证明了原有疾病影响的重要性。研究人群的规模和长期的随访期支持了结论的可靠性。
The aim of the present multicenter study was to assess long term (36 months) health related quality of life in patients after critical illness, compare ICU survivors health related quality of life to that of the general population and examine the impact of pre-existing disease and factors related to ICU care on health related quality of life. Prospective, longitudinal, multicentre trial in three combined medical and surgical intensive care units of one university and two general hospitals in Sweden. By mailed questionnaires, health related quality of life was assessed at 6, 12, 24 and 36 months after the stay in ICU by EQ-5D and SF-36, and information of pre-existing disease was collected at the 6 months measure. ICU related factors were obtained from the local ICU database. Comorbidity and health related quality of life (EQ-5D; SF-36) was examined in the reference group. Among the 5306 patients admitted, 1663 were considered eligible (>24 hrs in the intensive care unit, and age ≥ 18 yrs, and alive 6 months after discharge). At the 6 month measure 980 (59%) patients answered the questionnaire. Of these 739 (75%) also answered at 12 month, 595 (61%) at 24 month, and 478 (47%) answered at the 36 month measure. As reference group, a random sample (n = 6093) of people from the uptake area of the hospitals were used in which concurrent disease was assessed and adjusted for. Only small improvements were recorded in health related quality of life up to 36 months after ICU admission. The majority of the reduction in health related quality of life after care in the ICU was related to the health related quality of life effects of pre-existing diseases. No significant effect on the long-term health related quality of life by any of the ICU-related factors was discernible. A large proportion of the reduction in the health related quality of life after being in the ICU is attributable to pre-existing disease. The importance of the effect of pre-existing disease is further supported by the small, long term increment in the health related quality of life after treatment in the ICU. The reliability of the conclusions is supported by the size of the study populations and the long follow-up period.
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影响因子：
38.9
作者：
Angus, DC;Carlet, J
通讯作者：
Carlet, J
影响因子：
3.3
作者：
Brooks, R
通讯作者：
Brooks, R
影响因子：
10.7
作者：
Chrispin, PS;Scotton, H;Ridley, SA
通讯作者：
Ridley, SA
影响因子：
8.8
作者：
Wehler, M;Geise, A;Strauss, R
通讯作者：
Strauss, R
DOI：
10.1186/cc8848
发表时间：
2010
期刊：
Critical care (London, England)
影响因子：
--
作者：
Cuthbertson BH;Roughton S;Jenkinson D;Maclennan G;Vale L
通讯作者：
Vale L