Microbial adaptation to the healthy and inflamed gut environments.
Microbial adaptation to the healthy and inflamed gut environments.
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微生物对健康和发炎肠道环境的适应
DOI：
10.1080/19490976.2020.1857505
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发表时间：
2020-11-09
期刊：
影响因子：
12.2
通讯作者：
Kamada N
中科院分区：
文献类型：
--
作者：
Guo Y;Kitamoto S;Kamada N
摘要哺乳动物肠道中有100万亿种不同的细菌。共生细菌物种/菌株相互合作和竞争，以建立一个平衡的社区，对维持宿主健康至关重要。病原菌劫持合作机制或使用策略来逃避竞争机制以建立感染。此外，致病菌引起肠道中显著的环境变化，例如诱导炎症，这促进了病原体的选择性生长。本文综述了近年来关于肠道细菌种/株通过合作或竞争行为在肠道定植的机制的最新研究结果。我们还回顾了致病菌适应发炎肠道并以肠道细菌为代价茁壮成长的机制。了解细菌对健康和发炎肠道的适应性可能会提供新的细菌靶向治疗方法，选择性地促进有益肠道细菌的扩张或限制致病细菌的生长。
ABSTRACT There are 100 trillion diverse bacterial residents in the mammalian gut. Commensal bacterial species/strains cooperate and compete with each other to establish a well-balanced community, crucial for the maintenance of host health. Pathogenic bacteria hijack cooperative mechanisms or use strategies to evade competitive mechanisms to establish infection. Moreover, pathogenic bacteria cause marked environmental changes in the gut, such as the induction of inflammation, which fosters the selective growth of pathogens. In this review, we summarize the latest findings concerning the mechanisms by which commensal bacterial species/strains colonize the gut through cooperative or competitive behaviors. We also review the mechanisms by which pathogenic bacteria adapt to the inflamed gut and thrive at the expense of commensal bacteria. The understanding of bacterial adaptation to the healthy and the inflamed gut may provide new bacteria-targeted therapeutic approaches that selectively promote the expansion of beneficial commensal bacteria or limit the growth of pathogenic bacteria.
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影响因子：
6.7
作者：
Crawford RW;Keestra AM;Winter SE;Xavier MN;Tsolis RM;Tolstikov V;Bäumler AJ
通讯作者：
Bäumler AJ
影响因子：
56.9
作者：
Diard, Mederic;Bakkeren, Erik;Hardt, Wolf-Dietrich
通讯作者：
Hardt, Wolf-Dietrich
细菌-上皮接触是宿主对致病性和肠聚集性大肠杆菌的先天免疫反应的关键决定因素。
影响因子：
3.7
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Phillips AD
影响因子：
16.6
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Roe AJ
影响因子：
6.4
作者：
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