Is the Brainstem Activation Different Between Healthy Young Male and Female Volunteers at Initiation of Voiding? A High Definition 7-Tesla Magnetic Resonance Imaging Study.
Is the Brainstem Activation Different Between Healthy Young Male and Female Volunteers at Initiation of Voiding? A High Definition 7-Tesla Magnetic Resonance Imaging Study.
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DOI：
10.5213/inj.2346104.052
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发表时间：
2023-09
影响因子：
2.3
通讯作者：
Khavari R
中科院分区：
文献类型：
--
作者：
Schott B;Choksi D;Tran K;Karmonik C;Salazar B;Boone T;Khavari R
通过典型的神经成像方式评估人类脑干功能一直具有挑战性。我们的目的是评估大脑和脑干激活模式在开始排尿期间，在健康男性和女性使用7特斯拉磁共振成像（MRI）扫描仪和非侵入性脑膀胱功能MRI（fMRI）协议。招募了20名无泌尿系统症状史的健康成年志愿者（10名男性和10名女性）。每名志愿者都接受了诊所尿流和排泄后残留评估，并被要求在进入扫描仪前饮水。首先获得解剖和弥散张量图像，然后在膀胱排空期间进行血氧水平依赖性（BOLD）静息态fMRI（rs-fMRI）。受试者指出他们何时感到排尿的冲动，并获得完整的膀胱rs-fMRI。完成后，受试者开始5个排尿周期，其中每个排尿周期的前7.5秒被确定为“排尿开始”。生成BOLD激活图，t值大于2.1的感兴趣区域被认为具有统计学显著性。我们提出了5个不同的区域内的中脑导水管周围灰质（PAG）和脑桥排尿中心（PMC）与统计学显着激活与排尿的开始在男性和女性，3内的PAG和2内的PMC。大脑中的其他几个区域也被激活。当比较雄性与雌性时，在雌性的所有区域中观察到总体较低的BOLD激活，尾状叶除外。我们的研究有效地定义了健康志愿者中参与排尿启动的PAG和PMC内的区域。据我们所知，这是第一项利用超高清7 T MRI研究男性和女性脑干激活差异的研究。
Assessing brainstem function in humans through typical neuroimaging modalities has been challenging. Our objective was to evaluate brain and brainstem activation patterns during initiation of voiding in healthy males and females utilizing a 7 Tesla magnetic resonance imaging (MRI) scanner and a noninvasive brain-bladder functional MRI (fMRI) protocol. Twenty healthy adult volunteers (10 males and 10 females) with no history of urinary symptoms were recruited. Each volunteer underwent a clinic uroflow and postvoid residual assessment and was asked to consume water prior to entering the scanner. Anatomical and diffusion tensor images were obtained first, followed by a blood oxygenation level dependent (BOLD) resting-state fMRI (rs-fMRI) during the empty bladder. Subjects indicated when they felt the urge to void, and a full bladder rs-fMRI was obtained. Once completed, the subjects began 5 voiding cycles, where the first 7.5 seconds of each voiding cycle was identified as “initiation of voiding.” BOLD activation maps were generated, and regions of interests with a t-value greater than 2.1 were deemed statistically significant. We present 5 distinct regions within the periaqueductal gray (PAG) and pontine micturition center (PMC) with statistically significant activation associated with an initiation of voiding in both men and women, 3 within the PAG and 2 within the PMC. Several additional areas in the brain also demonstrated activation as well. When comparing males to females, there was an overall lower BOLD activation seen in females throughout all regions, with the exception of the caudate lobe. Our study effectively defines regions within the PAG and PMC involved in initiation of voiding in healthy volunteers. To our knowledge, this is the first study investigating differences between male and female brainstem activation utilizing an ultra-high definition 7T MRI.
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影响因子：
4.6
作者：
Mawla I;Schrepf A;Ichesco E;Harte SE;Klumpp DJ;Griffith JW;Strachan E;Yang CC;Lai H;Andriole G;Magnotta VA;Kreder K;Clauw DJ;Harris RE;Clemens JQ;Landis JR;Mullins C;Rodriguez LV;Mayer EA;Kutch JJ
通讯作者：
Kutch JJ
影响因子：
3.7
作者：
Isaacs BR;Mulder MJ;Groot JM;van Berendonk N;Lute N;Bazin PL;Forstmann BU;Alkemade A
通讯作者：
Alkemade A
影响因子：
23.4
作者：
Irwin, Debra E.;Milsom, Ian;Abrams, Paul
通讯作者：
Abrams, Paul
影响因子：
14.5
作者：
Blok, BFM;Sturms, LM;Holstege, G
通讯作者：
Holstege, G
影响因子：
2.2
作者：
Lai, H. Henry;Naliboff, Bruce;Harte, Steven E.
通讯作者：
Harte, Steven E.