Monocyte Chemoattractant Protein 1 (MCP-1) in obesity and diabetes.

Monocyte Chemoattractant Protein 1 (MCP-1) in obesity and diabetes.
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DOI:
10.1016/j.cyto.2012.06.018
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发表时间:
2012-10
期刊:
影响因子:
3.8
通讯作者:
Panee, Jun
Panee, Jun
中科院分区:
医学3区
文献类型:
--
作者:
Panee, Jun

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Monocyte chemoattractant protein-1 (MCP-1) is the first discovered and most extensively studied CC chemokine, and the amount of studies on its role in the etiologies of obesity- and diabetes-related diseases have increased exponentially during the past 2 decades. This review attempted to provide a panoramic perspective of the history, regulatory mechanisms, functions, and therapeutic strategies of this chemokine. The highlights of this review include the roles of MCP-1 in the development of obesity, diabetes, cardiovascular diseases, insulitis, diabetic nephropathy, and diabetic retinopathy. Therapies that specifically or non-specifically inhibit MCP-1 overproduction have been summarized.
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