Association of monocyte chemoattractant protein-1 with adipocyte number, insulin resistance and liver function markers.
Association of monocyte chemoattractant protein-1 with adipocyte number, insulin resistance and liver function markers.
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DOI：
10.1111/j.1600-0684.2009.00379.x
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发表时间：
2009-12
影响因子：
0.7
通讯作者：
Comuzzie AG
中科院分区：
文献类型：
--
作者：
Bose T;Alvarenga JC;Tejero ME;Voruganti VS;Proffitt JM;Freeland-Graves JH;Cole SA;Comuzzie AG
单核细胞趋化蛋白-1 (MCP-1) 是一种炎症趋化因子，已知可诱导脂肪细胞去分化和胰岛素抵抗。炎症、胰岛素抵抗和肥胖与非酒精性脂肪肝病 (NAFLD) 的发病机制有关。对 43 只狒狒的空腹血浆进行了 MCP-1、胰岛素、葡萄糖、丙氨酸转氨酶 (ALT) 和天冬氨酸转氨酶 (AST) 的检测。通过网膜脂肪组织的活检来测量脂肪细胞的数量和体积。稳态模型评估方法（HOMA）用于评估全身胰岛素抵抗。性别和年龄调整后的 MCP-1 与脂肪细胞数量 (r = -0.42; P = 0.01)、脂肪细胞体积 (r = 0.38; P = 0.02)、HOMA (r = 0.45; P = 0.004)、ALT (r = 0.46; P = 0.03) 和 AST (r = 0.45; P = 0.03) 和 AST (r = 0.45; P = 0.03）。这些结果表明MCP-1与脂肪细胞去分化和全身胰岛素抵抗有关，从而可能促进NAFLD的发展。
Monocyte chemoattractant protein-1 (MCP-1) is an inflammatory chemokine known to induce adipocyte dedifferentiation and insulin resistance. Inflammation, insulin resistance, and obesity have been implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Fasting plasma from 43 baboons were assayed for MCP-1, insulin, glucose, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Adipocyte number and volume were measured via biopsies of omental adipose tissue. The homeostatic model assessment method (HOMA) was used to estimate systemic insulin resistance. Sex and age adjusted correlations were significant for MCP-1 with adipocyte number (r = −0.42; P = 0.01), adipocyte volume (r = 0.38; P = 0.02), HOMA (r = 0.45; P = 0.004), ALT (r = 0.46; P = 0.03) and AST (r = 0.45; P = 0.03). These results suggest that MCP-1 is related with adipocyte dedifferentiation and systemic insulin resistance, thereby potentially contributing to the development of NAFLD.
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