Personalized vaccinology: A review.
Personalized vaccinology: A review.
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DOI：
10.1016/j.vaccine.2017.07.062
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发表时间：
2018-08-28
期刊：
影响因子：
5.5
通讯作者：
Kennedy RB
中科院分区：
文献类型：
--
作者：
Poland GA;Ovsyannikova IG;Kennedy RB
目前，疫苗学领域在许多方面仍然是经验主义的。疫苗开发、疫苗免疫原性和疫苗功效在历史上大部分由经验性的“分离-再注射”范式驱动。反过来，在预防可用疫苗预防的传染病方面，“每种疾病对每个人使用相同剂量”的人口一级公共卫生模式一直是规范性思维。此外，直到最近，还没有专门设计疫苗来克服衰老的免疫衰老，这与二战后为儿童开发疫苗和疫苗计划的心态一致。现在认识到，目前缺乏关于如何产生对疫苗的免疫应答的知识，这是理解老年人和免疫不成熟人群中疫苗应答差、发现疫苗免疫原性的新相关性（疫苗应答生物标志物）以及开发新疫苗的直接方法的关键障碍。疫苗组学和不良组学的新领域提供了允许在系统生物学水平上整合先天性、体液和细胞免疫应答的全球概况的模型。通过揭示免疫系统和其他生物系统之间和内部的新的相互作用（超越转录水平），这使科学超越了还原主义的科学方法，这对于发展对传染性病原体和疫苗的“下游”适应性体液和细胞反应至关重要。其他人已经将系统水平的方法应用于抗体应答的研究（a.k.a.“系统血清学”），[1]通过CyTOF的高维细胞亚群免疫表型分析，[2，3]和疫苗诱导的代谢变化[4]。反过来，这些知识被用来更好地了解以下内容：确定谁有感染的风险;存在关于免疫原性差和/或严重不良事件的风险水平;以及充分保护个人所需的疫苗类型或剂量。总的来说，这种方法允许个性化的方法来实践疫苗学，类似于个性化医学在人类健康和医学的其他领域中发挥的实质性作用。在此，我们简要回顾了疫苗组学，不良组学和个性化疫苗学领域。
At the current time, the field of vaccinology remains empirical in many respects. Vaccine development, vaccine immunogenicity, and vaccine efficacy have, for the most part, historically been driven by an empiric “isolate-inactivate-inject” paradigm. In turn, a population-level public health paradigm of “the same dose for everyone for every disease” model has been the normative thinking in regard to prevention of vaccine-preventable infectious diseases. In addition, up until recently, no vaccines had been designed specifically to overcome the immunosenescence of aging, consistent with a post-WWII mentality of developing vaccines and vaccine programs for children. It is now recognized that the current lack of knowledge concerning how immune responses to vaccines are generated is a critical barrier to understanding poor vaccine responses in the elderly and in immunoimmaturity, discovery of new correlates of vaccine immunogenicity (vaccine response biomarkers), and a directed approach to new vaccine development. The new fields of vaccinomics and adversomics provide models that permit global profiling of the innate, humoral, and cellular immune responses integrated at a systems biology level. This has advanced the science beyond that of reductionist scientific approaches by revealing novel interactions between and within the immune system and other biological systems (beyond transcriptional level), which are critical to developing “downstream” adaptive humoral and cellular responses to infectious pathogens and vaccines. Others have applied systems level approaches to the study of antibody responses (a.k.a. “systems serology”), [1] high-dimensional cell subset immunophenotyping through CyTOF, [2,3] and vaccine induced metabolic changes [4]. In turn, this knowledge is being utilized to better understand the following: identifying who is at risk for which infections; the level of risk that exists regarding poor immunogenicity and/or serious adverse events; and the type or dose of vaccine needed to fully protect an individual. In toto, such approaches allow for a personalized approach to the practice of vaccinology, analogous to the substantial inroads that individualized medicine is playing in other fields of human health and medicine. Herein we briefly review the field of vaccinomics, adversomics, and personalized vaccinology.
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影响因子：
3.5
作者：
Eliakim, A;Swindt, C;Cooper, DM
通讯作者：
Cooper, DM
影响因子：
4.8
作者：
Cummins, Nathan W.;Weaver, Eric A.;Badley, Andrew D.
通讯作者：
Badley, Andrew D.
影响因子：
16.6
作者：
Fourati S;Cristescu R;Loboda A;Talla A;Filali A;Railkar R;Schaeffer AK;Favre D;Gagnon D;Peretz Y;Wang IM;Beals CR;Casimiro DR;Carayannopoulos LN;Sékaly RP
通讯作者：
Sékaly RP
DOI：
10.1126/science.aah6157
发表时间：
2016-09-09
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Abbink P;Larocca RA;De La Barrera RA;Bricault CA;Moseley ET;Boyd M;Kirilova M;Li Z;Ng'ang'a D;Nanayakkara O;Nityanandam R;Mercado NB;Borducchi EN;Agarwal A;Brinkman AL;Cabral C;Chandrashekar A;Giglio PB;Jetton D;Jimenez J;Lee BC;Mojta S;Molloy K;Shetty M;Neubauer GH;Stephenson KE;Peron JP;Zanotto PM;Misamore J;Finneyfrock B;Lewis MG;Alter G;Modjarrad K;Jarman RG;Eckels KH;Michael NL;Thomas SJ;Barouch DH
通讯作者：
Barouch DH
影响因子：
8.2
作者：
Beery AK;Zucker I
通讯作者：
Zucker I