Gold nanocages as photothermal transducers for cancer treatment.
Gold nanocages as photothermal transducers for cancer treatment.
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DOI：
10.1002/smll.200902216
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发表时间：
2010-04-09
期刊：
影响因子：
13.3
通讯作者：
Xia, Younan
中科院分区：
文献类型：
--
作者：
Chen, Jingyi;Glaus, Charles;Laforest, Richard;Zhang, Qiang;Yang, Miaoxian;Gidding, Michael;Welch, Michael J.;Xia, Younan
金纳米笼代表了一类新的纳米材料，具有紧凑的尺寸和可调的光学性能，可用于生物医学应用。它们在近红外区表现出很强的光吸收，在那里光可以深入软组织。在聚乙二醇化后，金纳米笼可以被动地输送到动物的肿瘤中。聚乙二醇化金纳米笼的组织分布分析表明，注射后96h的肿瘤摄取率为5.7%ID/g。Au纳米笼不仅存在于肿瘤表面，而且存在于肿瘤的核心。通过近红外半导体激光(0.7W/cm~2，CW，λ=808 nm)照射肿瘤10min，金纳米笼的光热效应可以选择性地破坏肿瘤组织，对周围健康组织的损害最小。功能性[18F]氟代葡萄糖正电子发射断层扫描数据显示，光热治疗后肿瘤代谢活性降低。组织学检查发现肿瘤细胞核和肿瘤间质广泛受损。
Gold nanocages represent a new class of nanomaterials with compact size and tunable optical properties for biomedical applications. They exhibit strong light absorption in the near-infrared region in which light can penetrate deeply into soft tissue. After PEGylation, the Au nanocages can be passively delivered to tumors in animals. Analysis of tissue distribution for the PEGylated Au nanocages showed that the tumor uptake was 5.7 %ID/g at 96 h post injection. The Au nanocages were found not only on the surface, but also in the core of the tumor. By exposing tumors to a near-infrared diode laser (0.7 W/cm2, CW, λ=808 nm) for 10 min, the photothermal effect of the Au nanocages could selectively destroy tumor tissue with minimum damage to the surrounding healthy tissue. Data from functional [18F]fluorodexoyglucose positron emission tomography revealed a decrease in tumor metabolic activity upon the photothermal treatment. Histological examination identified extensive damage to the nuclei of tumor cells and tumor interstitium.
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DOI：
10.1073/pnas.2232479100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Hirsch, LR;Stafford, RJ;West, JL
通讯作者：
West, JL
影响因子：
8.6
作者：
Gou, LF;Murphy, CJ
通讯作者：
Murphy, CJ
影响因子：
10.8
作者：
Chen, Jingyi;Wang, Danling;Li, Xingde
通讯作者：
Li, Xingde
影响因子：
5.7
作者：
Melancon, Marites P.;Lu, Wei;Li, Chun
通讯作者：
Li, Chun
影响因子：
17.1
作者：
Au, Leslie;Zheng, Desheng;Zhou, Fei;Li, Zhi-Yuan;Li, Xingde;Xia, Younan
通讯作者：
Xia, Younan