Principles Governing Locomotion in Vertebrates: Lessons From Zebrafish.
Principles Governing Locomotion in Vertebrates: Lessons From Zebrafish.
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DOI：
10.3389/fncir.2018.00073
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发表时间：
2018
影响因子：
3.5
通讯作者：
El Manira A
中科院分区：
文献类型：
--
作者：
Berg EM;Björnfors ER;Pallucchi I;Picton LD;El Manira A
运动行为对生存至关重要，使动物能够在环境中导航，寻找食物，并躲避捕食者。一个多世纪以来，许多物种对启动和维持脊椎动物这种不同运动方式的大脑和脊髓回路进行了研究。近几十年来，斑马鱼由于其实验适应性而成为研究运动的主要模型系统之一，对斑马鱼的研究揭示了许多关于运动回路功能的新见解。在这里，我们回顾了导致我们目前对斑马鱼控制游泳和逃逸的神经回路的理解的文献。我们重点介绍最近的研究，这些研究丰富了我们对关键主题的理解，如运动前兴奋性中间神经元(INS)和运动神经元(MN)之间的相互作用，协调逃逸动作的脊髓上和脊髓回路，以及整体回路组成的发育变化。我们还讨论了神经调节器和感觉输入在改变组成电路组件的相对强度中的作用，以提供斑马鱼行为的灵活性，使动物能够适应环境的变化。我们的目标是提供一个连贯的框架，以了解斑马鱼大脑和脊髓中的电路，使动物能够灵活地在不同的运动速度和模式之间转换。
Locomotor behaviors are critical for survival and enable animals to navigate their environment, find food and evade predators. The circuits in the brain and spinal cord that initiate and maintain such different modes of locomotion in vertebrates have been studied in numerous species for over a century. In recent decades, the zebrafish has emerged as one of the main model systems for the study of locomotion, owing to its experimental amenability, and work in zebrafish has revealed numerous new insights into locomotor circuit function. Here, we review the literature that has led to our current understanding of the neural circuits controlling swimming and escape in zebrafish. We highlight recent studies that have enriched our comprehension of key topics, such as the interactions between premotor excitatory interneurons (INs) and motoneurons (MNs), supraspinal and spinal circuits that coordinate escape maneuvers, and developmental changes in overall circuit composition. We also discuss roles for neuromodulators and sensory inputs in modifying the relative strengths of constituent circuit components to provide flexibility in zebrafish behavior, allowing the animal to accommodate changes in the environment. We aim to provide a coherent framework for understanding the circuitry in the brain and spinal cord of zebrafish that allows the animal to flexibly transition between different speeds, and modes, of locomotion.
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影响因子：
5.3
作者：
Brustein, E;Drapeau, P
通讯作者：
Drapeau, P
DOI：
10.1073/pnas.1216256110
发表时间：
2012-12-26
影响因子：
11.1
作者：
Ausborn, Jessica;Mahmood, Riyadh;El Manira, Abdeljabbar
通讯作者：
El Manira, Abdeljabbar
影响因子：
2.5
作者：
BUCHANAN, JT;COHEN, AH
通讯作者：
COHEN, AH
影响因子：
16.2
作者：
Cachope, Roger;Mackie, Ken;Pereda, Alberto E.
通讯作者：
Pereda, Alberto E.
影响因子：
9.2
作者：
Bianco, Isaac H.;Engert, Florian
通讯作者：
Engert, Florian