Visuomotor transformations underlying hunting behavior in zebrafish.
Visuomotor transformations underlying hunting behavior in zebrafish.
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DOI：
10.1016/j.cub.2015.01.042
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发表时间：
2015-03-30
期刊：
影响因子：
9.2
通讯作者：
Engert, Florian
中科院分区：
文献类型：
--
作者：
Bianco, Isaac H.;Engert, Florian
视觉回路过滤视觉信息，并决定是否启动下游的运动模块来产生行为输出。然而，介导和链接的显着刺激的感知执行的适应性反应的电路机制知之甚少。我们结合了虚拟狩猎实验与双光子功能性钙成像，同时监测神经元活动的视顶盖在自然行为的系留幼斑马鱼。狩猎反应表现出混合选择性的视觉特征的组合，特别是刺激的大小，速度和对比度极性。我们确定了一个子集的顶盖神经元具有类似的高度选择性调谐，这表明非线性混合选择性的视觉功能，并可能介导的感知识别猎物。通过比较反应与非反应试验期间视顶盖中的神经动力学，我们发现了运动前群体活动，特别是在狩猎行为开始之前，并表现出与运动变量相关的解剖定位。总之，视顶盖包含非线性混合选择性神经元，这些神经元可能介导对行为学相关感觉刺激的可靠检测。招募小顶盖组件似乎链接感知行动提供前运动命令，释放狩猎反应。这些发现使我们能够提出一个模型电路的视觉转换的自然行为。斑马鱼狩猎反应是由视觉特征的连接触发的顶盖神经元对猎物样视觉刺激表现出非线性混合选择性顶盖组件表现出运动前活动，特别是在狩猎反应之前通过将虚拟狩猎试验与功能性钙成像相结合，Bianco和Engert确定了斑马鱼视顶盖中高度选择性的神经元，这些神经元可能是视觉猎物识别的基础。顶盖组件的招聘似乎通过提供释放狩猎反应的前运动命令将感知与行动联系起来。
Visuomotor circuits filter visual information and determine whether or not to engage downstream motor modules to produce behavioral outputs. However, the circuit mechanisms that mediate and link perception of salient stimuli to execution of an adaptive response are poorly understood. We combined a virtual hunting assay for tethered larval zebrafish with two-photon functional calcium imaging to simultaneously monitor neuronal activity in the optic tectum during naturalistic behavior. Hunting responses showed mixed selectivity for combinations of visual features, specifically stimulus size, speed, and contrast polarity. We identified a subset of tectal neurons with similar highly selective tuning, which show non-linear mixed selectivity for visual features and are likely to mediate the perceptual recognition of prey. By comparing neural dynamics in the optic tectum during response versus non-response trials, we discovered premotor population activity that specifically preceded initiation of hunting behavior and exhibited anatomical localization that correlated with motor variables. In summary, the optic tectum contains non-linear mixed selectivity neurons that are likely to mediate reliable detection of ethologically relevant sensory stimuli. Recruitment of small tectal assemblies appears to link perception to action by providing the premotor commands that release hunting responses. These findings allow us to propose a model circuit for the visuomotor transformations underlying a natural behavior. Zebrafish hunting responses are triggered by conjunctions of visual features Tectal neurons show non-linear mixed selectivity for prey-like visual stimuli Tectal assemblies show premotor activity specifically preceding hunting responses By combining a virtual hunting assay with functional calcium imaging, Bianco and Engert identify highly selective neurons in the zebrafish optic tectum that are likely to underlie visual prey recognition. The recruitment of tectal assemblies appears to link perception to action by providing the premotor commands that release hunting responses.
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影响因子：
3.5
作者：
Engert, Florian
通讯作者：
Engert, Florian
影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
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期刊：
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影响因子：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
1.3
作者：
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