Modelling learning in Caenorhabditis elegans chemosensory and locomotive circuitry for T-maze navigation.
Modelling learning in Caenorhabditis elegans chemosensory and locomotive circuitry for T-maze navigation.
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DOI：
10.1111/ejn.15560
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发表时间：
2022-01
影响因子：
3.4
通讯作者：
Gourgou, Eleni
中科院分区：
文献类型：
--
作者：
Sakelaris, Bennet G.;Li, Zongyu;Sun, Jiawei;Banerjee, Shurjo;Booth, Victoria;Gourgou, Eleni
最近，报道了一种新型的秀丽隐杆线虫联想学习，其中线虫在空的T迷宫中学习到达目标臂，在它们成功地在类似的诱饵训练迷宫的同一侧臂中找到奖励（食物）之后。在这里，我们提出了一个简化的秀丽隐杆线虫化学感受和运动回路的数学模型，该模型复制了秀丽隐杆线虫在T迷宫中的导航，并预测了产生迷宫学习的潜在机制。基于已知的神经回路，模型回路通过调节驱动模拟运动的运动神经元活动来响应食物释放的化学线索。我们发现，通过调制中间神经元的活动，这样的电路可以调解迷宫学习获得转向偏置，即使在一个单一的培训课程。通过将模拟行为与通过实施定制迷宫跟踪算法提取的新实验视频数据进行比较，验证了在食物诱饵迷宫中的训练条件期间和在空迷宫中的测试条件期间的模拟线虫迷宫导航。我们的工作提供了一个数学框架，调查这种新的学习行为的神经机制在秀丽隐杆线虫。模型结果预测参与迷宫和空间学习的神经元成分，并确定目标神经元和潜在的神经机制，为未来的实验研究这种学习行为。我们提出了一个数学框架和一个模型的线虫化学感觉和运动电路，复制线虫的导航和学习在T-迷宫和预测的潜在机制。我们发现，通过调节中间神经元的活动，这样的电路可以通过获得转向偏置和加强关键的神经元连接来介导学习。模型结果预测参与迷宫学习的神经元成分，并为未来的实验确定潜在的目标。
Recently, a new type of Caenorhabditis elegans associative learning was reported, where nematodes learn to reach a target arm in an empty T‐maze, after they have successfully located reward (food) in the same side arm of a similar, baited, training maze. Here, we present a simplified mathematical model of C. elegans chemosensory and locomotive circuitry that replicates C. elegans navigation in a T‐maze and predicts the underlying mechanisms generating maze learning. Based on known neural circuitry, the model circuit responds to food‐released chemical cues by modulating motor neuron activity that drives simulated locomotion. We show that, through modulation of interneuron activity, such a circuit can mediate maze learning by acquiring a turning bias, even after a single training session. Simulated nematode maze navigation during training conditions in food‐baited mazes and during testing conditions in empty mazes is validated by comparing simulated behaviour with new experimental video data, extracted through the implementation of a custom‐made maze tracking algorithm. Our work provides a mathematical framework for investigating the neural mechanisms underlying this novel learning behaviour in C. elegans . Model results predict neuronal components involved in maze and spatial learning and identify target neurons and potential neural mechanisms for future experimental investigations into this learning behaviour. We present a mathematical framework and a model of C. elegans chemosensory and locomotive circuitry that replicates nematodes' navigation and learning in a T‐maze and predicts the underlying mechanisms. We show that, through modulation of interneuron activity, such a circuit can mediate learning by acquiring a turning bias and strengthening key neuronal connections. Model results predict neuronal components involved in maze learning and identify potential targets for future experiments.
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DOI：
10.1186/1755-7682-3-24
发表时间：
2010-10-06
期刊：
International archives of medicine
影响因子：
--
作者：
Arias-Carrión O;Stamelou M;Murillo-Rodríguez E;Menéndez-González M;Pöppel E
通讯作者：
Pöppel E
影响因子：
10.6
作者：
Chan, TF;Vese, LA
通讯作者：
Vese, LA
影响因子：
5.3
作者：
Branch, Sarah Y.;Sharma, Ramaswamy;Beckstead, Michael J.
通讯作者：
Beckstead, Michael J.
影响因子：
5.3
作者：
Hills, T;Brockie, PJ;Maricq, AV
通讯作者：
Maricq, AV
影响因子：
4.3
作者：
Arnatkevic̆iūtė A;Fulcher BD;Pocock R;Fornito A
通讯作者：
Fornito A