Ondansetron pharmacokinetics in pregnant women and neonates: towards a new treatment for neonatal abstinence syndrome.
Ondansetron pharmacokinetics in pregnant women and neonates: towards a new treatment for neonatal abstinence syndrome.
复制标题
DOI：
10.1002/cpt.5
复制
发表时间：
2015-02
影响因子：
6.7
通讯作者：
Drover, D. R.
中科院分区：
文献类型：
--
作者：
Elkomy, M. H.;Sultan, P.;Carvalho, B.;Peltz, G.;Wu, M.;Clavijo, C.;Galinkin, J. L.;Drover, D. R.
Ondansetron is the drug of choice to prevent nausea in women undergoing cesarean surgery and can be used to prevent neonatal abstinence syndrome (NAS). Pharmacokinetics of ondansetron has not been characterized in pregnant women or in newborns. A nonlinear mixed-effects modeling approach was used to analyze plasma samples obtained from 20 non-pregnant and 40 pregnant women following single administration of 4 or 8 mg ondansetron, from umbilical cord blood at delivery, and from neonates after birth. The analysis indicates that: ondansetron disposition is not affected by pregnancy (p>0.05), but influenced by dose (p<0.05), and is characterized by rapid transplacental transfer and longer elimination half-life in neonates compared to their mother. A dosing regimen for prevention of NAS was designed based on the model. The regimen involves IV administration of 4 mg to the mothers shortly before cord clamping, or oral administration of 0.07 mg/kg (or equivalently 0.04 mg/kg IV) to neonates.
登录
查看更多内容
DOI：
10.1111/j.1360-0443.2010.03170.x
发表时间：
2011-03
期刊：
Addiction (Abingdon, England)
影响因子：
--
作者：
Kraft WK;Dysart K;Greenspan JS;Gibson E;Kaltenbach K;Ehrlich ME
通讯作者：
Ehrlich ME
影响因子：
6.1
作者：
Lindbom, L;Pihlgren, P;Jonsson, N
通讯作者：
Jonsson, N
影响因子：
2.4
作者：
MAAS, U;KATTNER, E;OBLADEN, M
通讯作者：
OBLADEN, M
影响因子：
120.7
作者：
Patrick, Stephen W.;Schumacher, Robert E.;Davis, Matthew M.
通讯作者：
Davis, Matthew M.
影响因子：
3.8
作者：
COLTHUP, PV;FELGATE, CC;SCULLY, NL
通讯作者：
SCULLY, NL