Reactive retinal microglia, neuronal survival, and the formation of retinal folds and detachments.
Reactive retinal microglia, neuronal survival, and the formation of retinal folds and detachments.
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DOI：
10.1002/glia.22752
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发表时间：
2015-02
期刊：
影响因子：
6.2
通讯作者：
Milani-Nejad, Nima
中科院分区：
文献类型：
--
作者：
Fischer, Andy J.;Zelinka, Christopher;Milani-Nejad, Nima
Reactive microglia and macrophages are prevalent in damaged retinas. Accordingly, we investigate how the activation or ablation of microglia/macrophages influences the survival of neurons in the chick retina in vivo. We applied intraocular injections of interleukin 6 (IL6) to stimulate the reactivity of microglia/macrophages and clodronate-liposomes to ablate microglia/macrophages. Activation of the microglia/macrophages with IL6 delays the death of retinal neurons from N-methyl-D-aspartate (NMDA) -induced excitotoxicity. In addition, activation of microglia/macrophages combined with colchicine-mediated retinal damage diminished the survival of ganglion cells. Application of IL6 after an excitotoxic insult greatly exacerbates the damage, and causes widespread retinal detachments and folds, accompanied by accumulation of microglia/macrophages in the subretinal space. Damage-induced retinal folds and detachments were significantly reduced by the ablation of microglia/macrophages. We conclude that microglial reactivity is detrimental to the survival of ganglion cells in colchicine-damaged retinas and detrimental to the survival of photoreceptors in retinal folds. In addition, we conclude that IL6-treatment transiently protects amacrine and bipolar cells against an excitotoxic insult. We propose that suppressing reactivity of microglia/macrophages may be an effective means to lessen the damage and vision loss resulting from damage, in particular during retinal detachment injuries.
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影响因子：
6.2
作者：
Fischer, Andy J.;Scott, Melissa A.;Zelinka, Christopher;Sherwood, Patrick
通讯作者：
Sherwood, Patrick
影响因子：
3.7
作者：
Joachim SC;Gramlich OW;Laspas P;Schmid H;Beck S;von Pein HD;Dick HB;Pfeiffer N;Grus FH
通讯作者：
Grus FH
影响因子：
2.7
作者：
Fischer, Andy J.;Ritchey, Eric R.;Wynne, Angela
通讯作者：
Wynne, Angela
影响因子：
5.1
作者：
Fischer, Andy J.;Bongini, Rachel
通讯作者：
Bongini, Rachel
影响因子：
--
作者：
Aberg ND;Brywe KG;Isgaard J
通讯作者：
Isgaard J