Large Animal Models of Breast Cancer.

Large Animal Models of Breast Cancer.
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DOI:
10.3389/fonc.2022.788038
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发表时间:
2022
影响因子:
4.7
通讯作者:
Carlson MA
Carlson MA
中科院分区:
医学3区
文献类型:
--
作者:
Mondal P;Bailey KL;Cartwright SB;Band V;Carlson MA

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在这个小审查的地位,优点和缺点的大型动物模型的乳腺癌(BC)将进行讨论。虽然大多数大型动物BC模型的早期研究使用犬和猫受试者,但最近人们对猪BC模型的开发感兴趣,并在建模人类疾病方面取得了一些早期有希望的结果。简要回顾了广泛使用的啮齿类动物BC模型,为大型动物BC模型的工作提供背景。大型动物BC模型的可用性可以为BC研究提供额外的工具,包括人类大小的受试者和具有更大生物相关性的BC模型的可用性。
In this mini review the status, advantages, and disadvantages of large animal modeling of breast cancer (BC) will be discussed. While most older studies of large animal BC models utilized canine and feline subjects, more recently there has been interest in development of porcine BC models, with some early promising results for modeling human disease. Widely used rodent models of BC were briefly reviewed to give context to the work on the large animal BC models. Availability of large animal BC models could provide additional tools for BC research, including availability of human-sized subjects and BC models with greater biologic relevance.
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