Epidemiological and microbiome associations of Clostridioides difficile carriage in infancy and early childhood.
Epidemiological and microbiome associations of Clostridioides difficile carriage in infancy and early childhood.
复制标题
DOI：
10.1080/19490976.2023.2203969
复制
发表时间：
2023-01
期刊：
影响因子：
12.2
通讯作者：
中科院分区：
文献类型：
--
作者：
艰难梭菌（C. diff）的流行率有所上升，对卫生保健系统造成了重大的经济影响。虽然产毒艰难梭菌在婴儿期携带是公认的，但关于其纵向趋势、相关流行危险因素和肠道微生物组特征的数据有限。我们的纵向队列研究的目的是调查2岁以下儿童中产毒艰难梭菌定殖的流行率的时间变化，以及相关的流行病学和肠道微生物组特征。孕妇在产前被纳入研究，并在2年内连续收集其孩子的粪便样本。从817名儿童中收集了2608份粪便样本。411/817例（50%）为雄性，738/817例（90%）足月出生。产毒性diff检出率分别为7/569（1%）、116/624（19%）、221/606（37%）、227/574（40%）和18/235（8%）。在6米高的地方接受母乳喂养的婴儿在2米、6米和12米高的地方携带母乳的可能性比没有接受母乳喂养的婴儿要小。在2 m (p = 0.002, p < 0.0001, 6米,在12 m p = 0.022)。尽管在某些分类群的相对丰度上存在较小的差异，但在任何时间点上，有和没有产毒艰难梭菌携带的类群之间的潜在α或β多样性没有显著差异。在这项迄今为止最大的纵向队列研究中，注意到产毒C. diff携带者状态的高发率。儿童中的产毒艰难梭菌载体状态很可能是动态婴儿微生物组的短暂组成部分。
There has been an increase in the prevalence of Clostridioides difficile (C. diff) causing significant economic impact on the health care system. Although toxigenic C. diff carriage is recognized in infancy, there is limited data regarding its longitudinal trends, associated epidemiolocal risk factors and intestinal microbiome characteristics. The objectives of our longitudinal cohort study were to investigate temporal changes in the prevalence of toxigenic C.diff colonization in children up to 2 years, associated epidemiological and intestinal microbiome characteristics. Pregnant mothers were enrolled prenatally, and serial stool samples were collected from their children for 2 years. 2608 serial stool samples were collected from 817 children. 411/817 (50%) were males, and 738/817 (90%) were born full term. Toxigenic C.diff was detected in 7/569 (1%) of meconium samples, 116/624 (19%) of 2 m (month), 221/606 (37%) of 6 m, 227/574 (40%) of 12 m and 18/235 (8%) of 24 m samples. Infants receiving any breast milk at 6 m were less likely to be carriers at 2 m, 6 m and 12 m than those not receiving it. (p = 0.002 at 2 m, p < 0.0001 at 6 m, p = 0.022 at 12 m). There were no robust differences in the underlying alpha or beta diversity between those with and without toxigenic C. diff carriage at any timepoint, although small differences in the relative abundance of certain taxa were found. In this largest longitudinal cohort study to date, a high prevalence of toxigenic C. diff carrier state was noted. Toxigenic C. diff carrier state in children is most likely a transient component of the dynamic infant microbiome.
登录
查看更多内容
影响因子：
11.8
作者：
Leung J;Burke B;Ford D;Garvin G;Korn C;Sulis C;Bhadelia N
通讯作者：
Bhadelia N
影响因子：
4.8
作者：
Fletcher JR;Erwin S;Lanzas C;Theriot CM
通讯作者：
Theriot CM
影响因子：
2.3
作者：
Cui, Qing-Qing;Yang, Jing;Zhao, Jian-Hong
通讯作者：
Zhao, Jian-Hong
影响因子：
11.8
作者：
Johnson, Stuart;Lavergne, Valery;Wilcox, Mark H.
通讯作者：
Wilcox, Mark H.
影响因子：
3.7
作者：
Ferraris, Laurent;Couturier, Jeanne;Aires, Julio
通讯作者：
Aires, Julio