The strength of the antibody response to the nematode Ascaris lumbricoides inversely correlates with levels of B-Cell Activating Factor (BAFF).
The strength of the antibody response to the nematode Ascaris lumbricoides inversely correlates with levels of B-Cell Activating Factor (BAFF).
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DOI：
10.1186/1471-2172-15-22
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发表时间：
2014-06-07
期刊：
影响因子：
3
通讯作者：
Caraballo L
中科院分区：
文献类型：
--
作者：
Bornacelly A;Mercado D;Acevedo N;Caraballo L
B细胞活化因子（BAFF）是一种调节抗体产生的细胞因子。编码BAFF的基因多态性与蛔虫抗体应答相关，但与螨过敏原无关。在本研究中，我们评估了448名对照组和448名哮喘患者的BAFF与蛔虫和螨特异性抗体之间的关系。通过ELISA测量可溶性BAFF，通过qPCR测量BAFF mRNA。用流式细胞术分析BAFF及其受体（BAFF-R）的表面表达。蛔虫特异性IgE水平>第75百分位数的个体可溶性BAFF水平较低;蛔虫特异性IgG水平>第75百分位数的个体BAFF mRNA水平降低。总IgE和螨特异性IgE与BAFF水平无关。哮喘患者和对照组之间可溶性BAFF或mRNA水平无差异。CD 19 + B细胞表面BAFF-R的表达与BAFF水平在转录和蛋白水平上呈负相关。这些发现表明，BAFF水平的差异与蛔虫抗体反应的强度有关。
B-Cell Activating Factor (BAFF) is a cytokine regulating antibody production. Polymorphisms in the gene encoding BAFF were associated with the antibody response to Ascaris but not to mite allergens. In the present study we evaluated the relationship between BAFF and specific antibodies against Ascaris and mites in 448 controls and 448 asthmatics. Soluble BAFF was measured by ELISA and BAFF mRNA by qPCR. Surface expression of BAFF and its receptor (BAFF-R) was analyzed by flow cytometry. Individuals with specific IgE levels to Ascaris >75th percentile had lower levels of soluble BAFF; those with specific IgG levels to Ascaris >75th percentile had reduced BAFF mRNA. Total IgE and specific IgE to mites were not related to BAFF levels. There were no differences in soluble BAFF or mRNA levels between asthmatics and controls. There was an inverse relationship between the cell-surface expression of BAFF-R on CD19+ B cells and BAFF levels at the transcriptional and protein level. These findings suggest that differences in BAFF levels are related to the strength of the antibody response to Ascaris.
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DOI：
10.1084/jem.20130505
发表时间：
2014-01-13
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Goenka R;Matthews AH;Zhang B;O'Neill PJ;Scholz JL;Migone TS;Leonard WJ;Stohl W;Hershberg U;Cancro MP
通讯作者：
Cancro MP
影响因子：
--
作者：
Jee HM;Choi BS;Kim KW;Sohn MH;Han MY;Kim KE
通讯作者：
Kim KE
影响因子：
2.2
作者：
Geiger, SM;Massara, CL;Corrêa-Oliveira, R
通讯作者：
Corrêa-Oliveira, R
TACI和BAFF-R介导B细胞中的同种型切换。
影响因子：
15.3
作者：
Castigli, E;Wilson, SA;Scott, S;Dedeoglu, F;Xu, SL;Lam, KP;Bram, RJ;Jabara, H;Geha, RS
通讯作者：
Geha, RS
影响因子：
2.8
作者：
Acevedo, N.;Erler, A.;Caraballo, L.
通讯作者：
Caraballo, L.