Incidence and risk factors for tuberculosis in people living with HIV: cohort from HIV referral health centers in Recife, Brazil.
Incidence and risk factors for tuberculosis in people living with HIV: cohort from HIV referral health centers in Recife, Brazil.
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艾滋病毒患者的结核病的发病率和危险因素：来自巴西市的艾滋病毒转诊卫生中心的队列。
DOI：
10.1371/journal.pone.0063916
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Rodrigues LC
中科院分区：
文献类型：
--
作者：
Batista Jd;de Albuquerque Mde F;Maruza M;Ximenes RA;Santos ML;Montarroyos UR;de Barros Miranda-Filho D;Lacerda HR;Rodrigues LC
确定艾滋病毒感染者（PLHIV）中结核病的发病率和危险因素。观察性、前瞻性队列研究。2007年7月至2010年12月期间，共观察了2069名艾滋病毒感染者。采用Kaplan-Meier法估计无结核生存概率，采用Cox回归分析确定与结核发展相关的危险因素。无结核生存率（TB）为91%。结核病的发病率为每100人/年2.8例。当受试者CD4细胞计数<200细胞/mm3时，结核病的发病率较高；没有接受抗逆转录病毒治疗；在那些身体质量指数<18.5 kg/m2、贫血（或未进行贫血检测）、文盲或在进入队列时曾接受过结核病治疗的患者中。未接受潜伏性结核感染治疗的患者患结核病的风险（HR = 7.9）远高于结核菌素皮肤试验（TST）阴性的患者。TST≥5mm但未接受潜伏性结核感染治疗的患者即使有既往结核病史，也会增加发生结核病的风险。降低艾滋病毒感染者结核病风险的预防行动应包括适当的HAART治疗和对TST≥5mm的潜伏性结核感染的治疗。在个人和公共卫生层面严格实施潜伏性结核感染的治疗和针对艾滋病毒吸毒者的行动可以大大减少艾滋病毒感染者的结核病发病率。
To identify the incidence of and risk factors for tuberculosis in people living with HIV (PLHIV). Observational, prospective cohort study. A total of 2069 HIV-infected patients was observed between July 2007 and December 2010. The Kaplan-Meier method was used to estimate the probability of survival free of tuberculosis, and Cox regression analysis to identify risk factors associated with the development of tuberculosis. Survival free of tuberculosis (TB) was 91%. The incidence rate of tuberculosis was 2.8 per 100 persons/years. Incidence of tuberculosis was higher when subjects had CD4 cell count <200 cells/mm3; were not on antiretroviral therapy; in those who had, a body mass index <18.5 kg/m2, anemia (or were not tested for it), were illiterate or referred previous tuberculosis treatment at entry into the cohort. Those not treated for latent TB infection had a much higher risk (HR = 7.9) of tuberculosis than those with a negative tuberculin skin test (TST). Having a TST≥5 mm but not being treated for latent TB infection increased the risk of incident tuberculosis even in those with a history of previous tuberculosis. Preventive actions to reduce the risk of TB in people living with HIV should include an appropriate HAART and treatment for latent TB infection in those with TST≥5 mm. The actions towards enabling rigorous implementation of treatment of latent TB infection and targeting of PLHIV drug users both at the individual and in public health level can reduce substantially the incidence of TB in PLHIV.
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DOI：
10.1590/s0037-86822008000600001
发表时间：
2008-12-01
影响因子：
2
作者：
Lannoy, Leonor Henriette de;Cortez-Escalante, Juan José;Romero, Gustavo Adolfo Sierra
通讯作者：
Romero, Gustavo Adolfo Sierra
影响因子：
11.8
作者：
Elzi, Luigia;Schlegel, Matthias;Furrer, Hansjakob
通讯作者：
Furrer, Hansjakob
DOI：
10.1086/594126
发表时间：
2009-01-01
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Deiss RG;Rodwell TC;Garfein RS
通讯作者：
Garfein RS
影响因子：
3.8
作者：
de Pinho, AMF;Santoro-Lopes, G;Schechter, M
通讯作者：
Schechter, M
DOI：
10.1590/s0102-311x2008000400020
发表时间：
2008-04-01
期刊：
Cadernos de Saúde Pública
影响因子：
--
作者：
Domingos, Mirian Pereira;Caiaffa, Waleska Teixeira;Colosimo, Enrico Antônio
通讯作者：
Colosimo, Enrico Antônio