The Effects of Cardiometabolic Factors on the Association Between Serum Uric Acid and Chronic Kidney Disease in Chinese Middle-Aged and Older Population: A Mediation Analysis.
The Effects of Cardiometabolic Factors on the Association Between Serum Uric Acid and Chronic Kidney Disease in Chinese Middle-Aged and Older Population: A Mediation Analysis.
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心脏代谢因素对中国中老年人群血尿酸与慢性肾脏病关系的中介分析
DOI：
10.3389/fendo.2021.702138
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发表时间：
2021
影响因子：
5.2
通讯作者：
Song Y
中科院分区：
文献类型：
--
作者：
Xu L;Sun H;Liu L;Zhan S;Wang S;Lv X;Song Y
探讨血脂异常、高血糖、高血压是否在血清尿酸（SUA）与慢性肾脏疾病（CKD）发生的关系中起中介作用。方法通过中介分析，探讨收缩压（SBP）、舒张压（DBP）、血糖、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）对SUA与肾小球滤过率（eGFR）之间关系的潜在中介作用。数据来自中国健康与退休纵向研究（CHARLS），涵盖5,762人。结果SUA对eGFR有负的剂量反应效应（β -3.11, 95% CI -3.40 ~ -2.82， p值<0.001）。SUA和七个潜在的介质之间的线性回归表明,血糖(β0.80,95%可信区间0.18到1.42,p = 0.012), TG(β10.01,95%可信区间8.22到11.79,p < 0.001), TC(β2.64,95%可信区间1.83到3.45,p < 0.001),高密度脂蛋白胆固醇(β-0.27,95%可信区间-0.52到-0.02,p = 0.034)和低密度脂蛋白(β1.15,95%可信区间0.49到1.80,p = 0.001)都有显著的剂量效应与安和苏阿,但是SBP和菲律宾与安和苏阿显示没有明显的联系。在潜在介质与eGFR之间的相关性方面，只有TG （β 0.003, 95% CI -0.001 ~ 0.01， p值=0.117）和HDL-C （β 0.01, 95% CI -0.02 ~ 0.04， p值=0.444）与eGFR没有显著的线性相关性。线性回归结果显示SUA与eGFR直接相关（p值<0.001）。结论：本研究支持SUA与CKD风险之间的关联不是由高血压、高血糖或血脂异常介导的。
Introduction To explore whether dyslipidemia, hyperglycemia or hypertension has mediating effect on the association between serum uric acid (SUA) and the development of chronic kidney disease (CKD). Methods We conducted a mediation analysis to explore the potential mediating effects of systolic blood pressure (SBP), diastolic blood pressure (DBP), blood glucose, triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) on the association between SUA and estimated glomerular filtration rate (eGFR). The data were obtained from China Health and Retirement Longitudinal Study (CHARLS), covering 5,762 individuals. Results SUA had a negative dose-response total effect on eGFR (β -3.11, 95% CI -3.40 to -2.82, P-value<0.001). The linear regression between SUA and seven potential mediators indicated that blood glucose (β 0.80, 95% CI 0.18 to 1.42, P-value=0.012), TG (β 10.01, 95% CI 8.22 to 11.79, P-value<0.001), TC (β 2.64, 95% CI 1.83 to 3.45, P-value<0.001), HDL-C (β -0.27, 95% CI -0.52 to -0.02, P-value=0.034) and LDL-C (β 1.15, 95% CI 0.49 to 1.80, P-value=0.001) all had significant dose-response association with SUA, but SBP and DBP showed no significant association with SUA. In terms of the association between potential mediators and eGFR, only TG (β 0.003, 95% CI -0.001 to 0.01, P-value=0.117) and HDL-C (β 0.01, 95% CI -0.02 to 0.04, P-value=0.444) did not have significant linear association with eGFR. The linear regression showed that SUA was directly associated with eGFR (P-value<0.001). Conclusions This study supported that the association between SUA and the risk of CKD was not mediated by hypertension, hyperglycemia or dyslipidemia.
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影响因子：
19.6
作者：
Khosla, UM;Zharikov, S;Johnson, RJ
通讯作者：
Johnson, RJ
影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
DOI：
10.1056/nejmoa1114248
发表时间：
2012-07-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Inker LA;Schmid CH;Tighiouart H;Eckfeldt JH;Feldman HI;Greene T;Kusek JW;Manzi J;Van Lente F;Zhang YL;Coresh J;Levey AS;CKD-EPI Investigators
通讯作者：
CKD-EPI Investigators
影响因子：
4.3
作者：
Li, Li;Song, Qifa;Yang, Xi
通讯作者：
Yang, Xi
影响因子：
168.9
作者：
Jha, Vivekanand;Garcia-Garcia, Guillermo;Yang, Chih-Wei
通讯作者：
Yang, Chih-Wei