Sodium Pentobarbitone and the Suppression of Luteinizing Hormone Pulses in the Female Rat: the Role of Hypothermia
Sodium Pentobarbitone and the Suppression of Luteinizing Hormone Pulses in the Female Rat: the Role of Hypothermia
复制标题
戊巴比妥钠和雌性大鼠黄体生成素脉冲的抑制：低温的作用
DOI：
10.1111/j.1365-2826.1996.tb00825.x
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发表时间：
1996
影响因子：
3.2
通讯作者：
C. Coen
中科院分区：
文献类型：
--
作者：
P. Strutton;C. Coen
在去卵巢大鼠模型上观察了低温对戊巴比妥钠抑制黄体生成素（LH）脉动释放的作用。每只动物均配有腹膜内微型无线电发射器以监测核心温度，并配有留置的静脉内和腹膜内导管。在6 h采样期间，每5 min自动记录一次动物的核心温度，同时使用自动化系统采集25 μl血样。在最初3 h采样后，通过笼外的腹膜内插管给予药物或溶媒，从而确保对动物的干扰最小。在21°C的环境温度下给予戊巴比妥钠（40 mg/kg）导致注射后3小时内体温显著降低。在此期间，平均LH浓度以及LH脉冲的频率和振幅显著降低。当在35°C的环境温度下给药时，核心温度没有降低，LH脉冲参数也没有显著变化。当在21°C或35°C的环境温度下给药时，溶剂处理对核心温度或LH脉冲参数无显著影响。这些结果表明，这种巴比妥类药物对LH脉冲释放的影响是继发于诱导的低温，并表明低温本身可能能够破坏LH脉冲。因此，有必要重新评估以前的研究，涉及特定的神经递质系统的LH脉冲的控制的意义;未识别的治疗的低温效应可能是脉冲抑制的主要原因，而不是直接参与的神经递质在LH释放激素的调节问题。低温状态可能抑制LH脉冲的神经生理过程仍有待确定。
The role of hypothermia in the suppression of pulsatile luteinizing hormone (LH) release by the barbiturate sodium pentobarbitone has been investigated in ovariectomized rats. Each animal was fitted with an intraperitoneal miniature radio transmitter to monitor core temperature and with an indwelling intravenous and intraperitoneal catheter. During the 6‐h sampling period the animal's core temperature was recorded automatically every 5 min and a 25 μl blood sample was obtained concurrently using an automated system. After the initial 3 h of sampling either the drug or the vehicle was administered via the intraperitoneal cannula from outside the cage, thus ensuring minimal disturbance to the animal. Administration of sodium pentobarbitone (40 mg/kg) at an ambient temperature of 21°C resulted in a significant hypothermia throughout the 3‐h post‐injection period. During this period there was a significant reduction in mean LH concentration, and in the frequency and amplitude of the LH pulses. When the drug was administered at an ambient temperature of 35°C there was no reduction in core temperature and no significant change in the LH pulse parameters. Vehicle treatment was without significant effect on core temperature or on the LH pulse parameters when administered at an ambient temperature of either 21°C or 35°C. These results indicate that the effects of this barbiturate on the pulsatile release of LH are secondary to the induced hypothermia and suggest that hypothermia per se may be able to disrupt LH pulses. It is therefore imperative to reassess the significance of previous studies that have implicated particular neurotransmitter systems in the control of LH pulses; unrecognized hypothermic effects of the treatments may have been the primary cause of the pulse suppression, rather than a direct involvement of the neurotransmitter in question in the regulation of LH releasing hormone. The neurophysiological process by which the hypothermic state may inhibit LH pulses remains to be determined.
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影响因子：
56.9
作者：
RIVIER, C;RIVIER, J;VALE, W
通讯作者：
VALE, W
神经肽 Y 影响卵巢切除大鼠黄体生成素和生长激素的分泌。
DOI：
10.1073/pnas.82.2.561
发表时间：
1985
影响因子：
11.1
作者：
McDonald,JK;Lumpkin,MD;Samson,WK;McCann,SM
通讯作者：
McCann,SM
低温在戊巴比妥诱导的雌性大鼠黄体生成素分泌阻断中的作用。
影响因子：
4.1
作者：
Simpkins,JW;Katovich,MJ
通讯作者：
Katovich,MJ
戊巴比妥、芬太尼-氟哌利多、氯胺酮-甲苯噻嗪和氯胺酮-地西泮对成年雄性大鼠核心和表面体温调节的影响。
DOI：
--
发表时间：
1987
期刊：
Laboratory animal science
影响因子：
--
作者：
Wixson,SK;White,WJ;HughesJr,HC;Lang,CM;Marshall,WK
通讯作者：
Marshall,WK
血管紧张素 II 对卵巢切除大鼠 LH 分泌的刺激或抑制作用：性腺类固醇的功能。
影响因子：
4.1
作者：
Steele,MK;Gallo,RV;Ganong,WF
通讯作者：
Ganong,WF