An elevated breathing reserve index at the lactate threshold is a predictor of mortality in patients with cystic fibrosis awaiting lung transplantation.
An elevated breathing reserve index at the lactate threshold is a predictor of mortality in patients with cystic fibrosis awaiting lung transplantation.
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乳酸阈值的呼吸储备指数升高是等待肺移植的囊性纤维化患者死亡率的预测因子。
DOI：
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发表时间：
2002
影响因子：
24.7
通讯作者：
L. Ginns
中科院分区：
文献类型：
--
作者：
K. Tantisira;D. Systrom;L. Ginns
囊性纤维化（CF）患者在肺移植等待名单上死亡的比例仍然很高;这类患者的识别仍然很困难。乳酸阈值（LT）下的呼吸储备指数（BRI =每分钟通气量/最大自主通气量）是递增运动的肺机械极限的预测因子。我们假设等待肺移植的CF患者LT时BRI升高是等待名单死亡率的预测因子。连续45例CF患者完成心肺运动试验，作为其移植前评估的一部分。我们通过考克斯比例风险模型评估了LT时的BRI、基线人口统计学特征、肺功能和其他运动参数。15名患者在等待移植时死亡。其中21人接受了移植，9人仍在等待移植。多变量模型的相对风险包括（括号内为95%置信区间）LT时的BRI，17.52（2.45-123.97）;静息Pa（CO（2）），1.29（1.10-1.49）;静息Pa（O（2）），0.97（0.90-1.05）; 1秒用力呼气量占预测值的百分比，1.19（1.05-1.34）。LT时的BRI不仅提供了等待名单死亡率风险的最高点估计值，而且还确定了处于风险中的患者的生理学显著阈值（0.70或更高）。这种测量可以改善移植的上市时间，包括考虑活体供体移植。
The proportion of cystic fibrosis (CF) patients dying while on the lung transplant wait list remains high; identification of such patients remains difficult. The breathing reserve index (BRI = minute ventilation/maximal voluntary ventilation) at the lactate threshold (LT) is a predictor of a pulmonary mechanical limit to incremental exercise. We hypothesized that an elevated BRI at the LT in patients with CF awaiting lung transplantation would be a predictor of wait list mortality. Forty-five consecutive patients with CF completed cardiopulmonary exercise testing as part of their pretransplant assessment. We evaluated BRI at LT, baseline demographic characteristics, pulmonary function, and other exercise parameters via Cox proportional hazards modeling. Fifteen patients died while awaiting transplant. Twenty one were transplanted, and nine still awaited transplantation. Relative risks from the multivariate model included (95% confidence interval in parentheses) BRI at LT, 17.52 (2.45-123.97); resting Pa(CO(2)), 1.29 (1.10-1.49); resting Pa(O(2)), 0.97 (0.90-1.05); and forced expiratory volume at one second as a percent of predicted, 1.19 (1.05-1.34). BRI at LT not only provided the highest point estimate of risk for wait list mortality but also identified a physiologically significant threshold value (0.70 or more) for those at risk. This measurement may allow improved timing of listing for transplantation, including consideration for living donor transplantation.
囊性纤维化肺移植后体重指数恢复。
影响因子：
8.3
作者：
Pryor,JosephB;Bradford,MirandaC;Jennerich,AnnL;Wai,TravisYHee;Pilewski,JosephM;Kapnadak,SiddharthaG;Aitken,MoiraL;Goss,ChristopherH;Ramos,KathleenJ
通讯作者：
Ramos,KathleenJ
运动通气控制中的骨骼肌化学反射和 pHi。
DOI：
10.1152/jappl.1998.84.2.676
发表时间：
1998
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Oelberg,DA;Evans,AB;Hrovat,MI;Pappagianopoulos,PP;Patz,S;Systrom,DM
通讯作者：
Systrom,DM
心力衰竭引起的劳力性呼吸困难：与静息或运动时肺功能无关的症状。
影响因子：
4.8
作者：
Russell,SD;McNeer,FR;Higginbotham,MB
通讯作者：
Higginbotham,MB