Metabolic phenotyping for discovery of urinary biomarkers of diet, xenobiotics and blood pressure in the INTERMAP Study: an overview.

Metabolic phenotyping for discovery of urinary biomarkers of diet, xenobiotics and blood pressure in the INTERMAP Study: an overview.
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DOI:
10.1038/hr.2016.164
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发表时间:
2017-04
期刊:
Hypertension research : official journal of the Japanese Society of Hypertension
影响因子:
--
通讯作者:
Elliott P
Elliott P
中科院分区:
其他
文献类型:
--
作者:
Chan Q;Loo RL;Ebbels TM;Van Horn L;Daviglus ML;Stamler J;Nicholson JK;Holmes E;Elliott P

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心血管疾病(CVD)的病因是多因素的。不良血压(BP)是流行性CVD的主要独立危险因素,影响全球约40%的成年人群,并导致显著的发病率和死亡率。生物流体的代谢表型已证明其在表征低分子量代谢物中的应用,提供了与疾病状态相关的基因-环境-肠道微生物组相互作用的新见解。在这篇综述中,我们综合了大量/微量营养素和血压的国际研究(INTERMAP)研究的关键结果,这是一项对来自日本、中华人民共和国、英国和美国的4,680名40-59岁男性和女性进行的横断面流行病学研究。我们描述了我们在以下方面取得的进展:1)高通量代谢表型分析技术; 2)生物标志物鉴定的统计分析; 3)发现独特的食物特异性生物标志物; 4)应用代谢组关联(MWA)研究更好地了解跨文化和区域BP差异的分子机制。
The aetiopathogenesis of cardiovascular diseases (CVD) is multifactorial. Adverse blood pressure (BP) is a major independent risk factor for epidemic CVD affecting about 40% of the adult population worldwide and resulting in significant morbidity and mortality. Metabolic phenotyping of biological fluids has proven its application in characterising low molecule weight metabolites providing novel insights into gene-environmental-gut microbiome interaction in relations to a disease state. In this review, we synthesise key results from the International Study of Macro/Micronutrients and Blood Pressure (INTERMAP) Study, a cross-sectional epidemiological study of 4,680 men and women aged 40–59 years from Japan, the People’s Republic of China, the United Kingdom, and the United States. We describe the advancements we have made on: 1) analytical techniques for high throughput metabolic phenotyping; 2) statistical analyses for biomarker identification; 3) discovery of unique food-specific biomarkers; and 4) application of metabolome-wide association (MWA) studies to gain a better understanding into the molecular mechanisms of cross cultural and regional BP differences.
DOI: 10.1038/nature10405
发表时间: 2011-09-11
期刊: NATURE
影响因子: 64.8
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