Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration: protocol for a systematic review with individual participant data meta-analysis of behavioural interventions for the prevention of early childhood obesity.
Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration: protocol for a systematic review with individual participant data meta-analysis of behavioural interventions for the prevention of early childhood obesity.
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转化儿童肥胖预防（TOPCHILD）协作：对儿童早期肥胖预防行为干预的个体参与者数据荟萃分析的系统评价方案。
DOI：
10.1136/bmjopen-2020-048166
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发表时间：
2022-01-20
期刊：
影响因子：
2.9
通讯作者：
Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration
中科院分区：
文献类型：
--
作者：
Hunter KE;Johnson BJ;Askie L;Golley RK;Baur LA;Marschner IC;Taylor RW;Wolfenden L;Wood CT;Mihrshahi S;Hayes AJ;Rissel C;Robledo KP;O'Connor DA;Espinoza D;Staub LP;Chadwick P;Taki S;Barba A;Libesman S;Aberoumand M;Smith WA;Sue-See M;Hesketh KD;Thomson JL;Bryant M;Paul IM;Verbestel V;Stough CO;Wen LM;Larsen JK;O'Reilly SL;Wasser HM;Savage JS;Ong KK;Salvy SJ;Messito MJ;Gross RS;Karssen LT;Rasmussen FE;Campbell K;Linares AM;Øverby NC;Palacios C;Joshipura KJ;González Acero C;Lakshman R;Thompson AL;Maffeis C;Oken E;Ghaderi A;Campos Rivera M;Pérez-Expósito AB;Banna JC;de la Haye K;Goran M;Røed M;Anzman-Frasca S;Taylor BJ;Seidler AL;Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration
生命早期的行为干预似乎在减少儿童超重和肥胖方面显示出一定效果。然而，其总体有效性以及在关键亚组之间有效性是否存在差异仍不确定。这些证据缺口促使全球范围内幼儿肥胖预防试验增多。综合这些试验的个体参与者数据（IPD）将提高统计效力以确定总体有效性，并能够对个体和试验层面的亚组进行检验。我们提出一项包含个体参与者数据元分析的系统综述方案，以评估从产前或出生后第一年开始的肥胖预防干预措施的有效性，并探究在关键亚组之间是否存在差异效应。
截至2021年3月，已完成对Medline、Embase、Cochrane对照试验中心注册库、护理及相关健康文献累积索引（CINAHL）、PsycInfo以及试验注册库的系统检索，以查找所有正在进行和已完成的评估儿童早期肥胖预防行为干预的随机对照试验，并将每年更新以纳入更多试验。符合条件的试验者将被要求分享他们的个体参与者数据；如果无法提供，将尽可能使用汇总数据。将使用Cochrane协作网推荐的方法进行个体参与者数据元分析和嵌套式前瞻性元分析。主要结局指标将是采用世界卫生组织生长标准的24±6个月龄时的体重指数z评分，并将在预先设定的个体和试验层面亚组中探究效应差异。次要结局包括其他与儿童体重相关的指标、婴儿喂养、饮食摄入、身体活动、久坐行为、睡眠、养育措施以及不良事件。
该研究已获悉尼大学人类研究伦理委员会（2020/273）和弗林德斯大学社会与行为研究伦理委员会（HREC CIA2133 - 1）批准。研究结果将与临床医生、儿童健康服务机构、研究人员、政策制定者和家庭相关，并将通过发表论文、报告和媒体发布等方式传播。
CRD42020177408
Behavioural interventions in early life appear to show some effect in reducing childhood overweight and obesity. However, uncertainty remains regarding their overall effectiveness, and whether effectiveness differs among key subgroups. These evidence gaps have prompted an increase in very early childhood obesity prevention trials worldwide. Combining the individual participant data (IPD) from these trials will enhance statistical power to determine overall effectiveness and enable examination of individual and trial-level subgroups. We present a protocol for a systematic review with IPD meta-analysis to evaluate the effectiveness of obesity prevention interventions commencing antenatally or in the first year after birth, and to explore whether there are differential effects among key subgroups. Systematic searches of Medline, Embase, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycInfo and trial registries for all ongoing and completed randomised controlled trials evaluating behavioural interventions for the prevention of early childhood obesity have been completed up to March 2021 and will be updated annually to include additional trials. Eligible trialists will be asked to share their IPD; if unavailable, aggregate data will be used where possible. An IPD meta-analysis and a nested prospective meta-analysis will be performed using methodologies recommended by the Cochrane Collaboration. The primary outcome will be body mass index z-score at age 24±6 months using WHO Growth Standards, and effect differences will be explored among prespecified individual and trial-level subgroups. Secondary outcomes include other child weight-related measures, infant feeding, dietary intake, physical activity, sedentary behaviours, sleep, parenting measures and adverse events. Approved by The University of Sydney Human Research Ethics Committee (2020/273) and Flinders University Social and Behavioural Research Ethics Committee (HREC CIA2133-1). Results will be relevant to clinicians, child health services, researchers, policy-makers and families, and will be disseminated via publications, presentations and media releases. CRD42020177408.
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影响因子：
1.9
作者：
Cox, Rachael;Skouteris, Helen;Hardy, Louise L.
通讯作者：
Hardy, Louise L.
影响因子：
20.8
作者：
Haire-Joshu D;Tabak R
通讯作者：
Tabak R
影响因子：
3.7
作者：
Dodd JM;Grivell RM;Louise J;Deussen AR;Giles L;Mol BW;Vinter C;Tanvig M;Jensen DM;Bogaerts A;Devlieger R;Luoto R;McAuliffe F;Renault K;Carlsen E;Geiker N;Poston L;Briley A;Thangaratinam S;Rogozinska E;Owens JA
通讯作者：
Owens JA
影响因子：
158.5
作者：
Geserick, Mandy;Vogel, Mandy;Koerner, Antje
通讯作者：
Koerner, Antje
基于家庭的儿童肥胖预防干预措施：系统评价和定量内容分析。
DOI：
10.1186/s12966-017-0571-2
发表时间：
2017-08-24
期刊：
The international journal of behavioral nutrition and physical activity
影响因子：
--
作者：
Ash T;Agaronov A;Young T;Aftosmes-Tobio A;Davison KK
通讯作者：
Davison KK