The effect of Parkinson's disease on the dynamics of on-line and proactive cognitive control during action selection.
The effect of Parkinson's disease on the dynamics of on-line and proactive cognitive control during action selection.
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DOI：
10.1162/jocn.2009.21326
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发表时间：
2010-09
影响因子：
3.2
通讯作者：
van den Wildenberg WP
中科院分区：
文献类型：
--
作者：
Wylie SA;Ridderinkhof KR;Bashore TR;van den Wildenberg WP
处理不相关的视觉信息有时会激活不正确的反应冲动。参与认知控制机制来抑制这些冲动，并作出积极的调整，以减少未来的影响，不正确的冲动可能依赖于完整的额基底神经节电路。使用西蒙的任务，我们调查的影响，基底神经节功能障碍产生的帕金森氏病（PD）的在线（试验内）和主动（试验间）控制的努力，以减少干扰所产生的激活不正确的反应。作为一个新的功能，我们应用分布分析，激活抑制模型的指导下，区分不正确的反应激活的强度和熟练的抑制从事对抗这种激活。对于需要在线控制的情况，PD组（n = 52）和健康对照组（n = 30）显示出相似的平均干扰效应（即，Simon效应）对反应时间（RT）和准确性的影响。分布分析表明，虽然不正确的反应冲动的强度是相似的组之间的PD患者不太精通抑制这些冲动。两组均表现出对平均RT和准确率的反应干扰的等效和有效的主动控制。然而，PD患者在主动减少不正确反应激活的强度方面效果较差。在帕金森病患者中，运动症状的严重程度与在线困难有关，但与主动控制反应冲动无关。这些结果表明，基底神经节功能障碍所产生的PD有选择性的影响认知控制机制参与解决反应冲突，与主要赤字的不正确的反应发生在一个相对备用的能力，主动调整控制，以尽量减少未来的冲突的背景下，在网上抑制。
Processing irrelevant visual information sometimes activates incorrect response impulses. The engagement of cognitive control mechanisms to suppress these impulses and make proactive adjustments to reduce the future impact of incorrect impulses may rely on the integrity of frontal–basal ganglia circuitry. Using a Simon task, we investigated the effects of basal ganglia dysfunction produced by Parkinson's disease (PD) on both on-line (within-trial) and proactive (between-trial) control efforts to reduce interference produced by the activation of an incorrect response. As a novel feature, we applied distributional analyses, guided by the activation–suppression model, to differentiate the strength of incorrect response activation and the proficiency of suppression engaged to counter this activation. For situations requiring on-line control, PD (n = 52) and healthy control (n = 30) groups showed similar mean interference effects (i.e., Simon effects) on reaction time (RT) and accuracy. Distributional analyses showed that although the strength of incorrect response impulses was similar between the groups PD patients were less proficient at suppressing these impulses. Both groups demonstrated equivalent and effective proactive control of response interference on mean RT and accuracy rates. However, PD patients were less effective at reducing the strength of incorrect response activation proactively. Among PD patients, motor symptom severity was associated with difficulties in on-line, but not in proactive, control of response impulses. These results suggest that basal ganglia dysfunction produced by PD has selective effects on cognitive control mechanisms engaged to resolve response conflict, with primary deficits in the on-line suppression of incorrect responses occurring in the context of a relatively spared ability to adjust control proactively to minimize future conflict.
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影响因子：
4.1
作者：
GRATTON, G;COLES, MGH;DONCHIN, E
通讯作者：
DONCHIN, E
影响因子：
2.3
作者：
Burle, B;Possamaï, CA;Hasbroucq, T
通讯作者：
Hasbroucq, T
影响因子：
2.9
作者：
Davelaar, Eddy J.
通讯作者：
Davelaar, Eddy J.
影响因子：
2.5
作者：
Cagigas, Xavier E.;Filoteo, J. Vincent;Friedrich, Frances J.
通讯作者：
Friedrich, Frances J.
影响因子：
3.3
作者：
Falkenstein, M.;Willemssen, R.;Hielscher, H.
通讯作者：
Hielscher, H.