On use of partial area under the ROC curve for evaluation of diagnostic performance.
On use of partial area under the ROC curve for evaluation of diagnostic performance.
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DOI：
10.1002/sim.5777
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发表时间：
2013-09-10
影响因子：
2
通讯作者：
Gur, David
中科院分区：
文献类型：
--
作者：
Ma, Hua;Bandos, Andriy I.;Rockette, Howard E.;Gur, David
关键词：
诊断性能评估是包括医疗诊断和决策在内的许多领域新发展的必要组成部分。对诊断绩效进行统计分析的方法在继续发展，为常规推断提供了新的分析工具，并为新的、越来越切合实际的问题提供了解决办法。在这篇文章中，我们关注的是接收器工作特性(ROC)曲线下的部分区域，即pAUC。这一综合指数被认为比整个ROC曲线下的面积(AUC)更切合实际，但由于几个明显的局限性，它没有被经常使用。为了改进解释，pAUC的分析结果经常使用重新标度的指数来报告，例如McClish(1989)提出的标准化部分AUC。我们得到了“标准化的”pAUC与定义的兴趣范围之间的关系的两个重要性质，这可能有助于这一重要的总结指数的更广泛和更适当的使用。首先，我们从数学上证明了对于实际常见的ROC曲线，“标准化”的pAUC随感兴趣范围的增大而增加。其次，使用全面的数值研究，我们证明，与通常的看法相反，估计的标准化pAUC的不确定性可以随着兴趣范围的增加而减少或增加。我们的结果表明，在估计的统计不确定性方面，部分AUC通常可以提供优势。此外，选择更广泛的兴趣可能会导致即使是标准化的pAUC的估计也会增加。
Evaluation of diagnostic performance is a necessary component of new developments in many fields including medical diagnostics and decision making. The methodology for statistical analysis of diagnostic performance continues to develop, offering new analytical tools for conventional inferences and solutions for novel and increasingly more practically relevant questions. In this paper we focus on the partial area under the Receiver Operating Characteristic (ROC) curve, or pAUC. This summary index is considered to be more practically relevant than the area under the entire ROC curve (AUC), but because of several perceived limitations, it is not used as often. In order to improve interpretation, results for pAUC analysis are frequently reported using a rescaled index such as the standardized partial AUC proposed by McClish (1989). We derive two important properties of the relationship between the “standardized” pAUC and the defined range of interest, which could facilitate a wider and more appropriate use of this important summary index. First, we mathematically prove that the “standardized” pAUC increases with increasing range of interest for practically common ROC curves. Second, using comprehensive numerical investigations we demonstrate that, contrary to common belief, the uncertainty about the estimated standardized pAUC can either decrease or increase with an increasing range of interest. Our results indicate that the partial AUC could frequently offer advantages in terms of statistical uncertainty of the estimation. In addition, selection of a wider range of interest will likely lead to an increased estimate even for standardized pAUC.
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影响因子：
3.6
作者：
MCCLISH, DK
通讯作者：
MCCLISH, DK
影响因子：
2.7
作者：
WIEAND, S;GAIL, MH;JAMES, KL
通讯作者：
JAMES, KL
影响因子：
19.7
作者：
Jiang, YL;Metz, CE;Nishikawa, RM
通讯作者：
Nishikawa, RM
影响因子：
3.8
作者：
Bandos, Andriy I.;Rockette, Howard E.;Gur, David
通讯作者：
Gur, David
影响因子：
5
作者：
Gur, David;Abrams, Gordon S.;Bandos, Andriy I.
通讯作者：
Bandos, Andriy I.