Low Birthweight as a Risk Factor for Non-communicable Diseases in Adults.
Low Birthweight as a Risk Factor for Non-communicable Diseases in Adults.
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DOI：
10.3389/fmed.2021.793990
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发表时间：
2021
影响因子：
3.9
通讯作者：
Restrepo JM
中科院分区：
文献类型：
--
作者：
Bianchi ME;Restrepo JM
根据过去40年进行的研究，出生体重不足不仅是围产期死亡和发病的重要预测因素，而且也增加了成年后患慢性非传染性疾病的风险。本文的目的是总结关于LBW作为成人NCD危险因素的研究。Barker假说的基础是，发现患有LBW或不健康宫内环境以及快速追赶的成年人死于NCD。在过去的几十年里，诸如节俭基因，胎儿编程，健康和疾病的发育起源（DOHaD）和表观遗传因素等术语已经被创造出来。最常见的非传染性疾病包括心血管疾病、2型糖尿病（DMT2）、高血压（HT）、血脂异常、蛋白尿和慢性肾病（CKD）。对经历过饥荒的母亲和那些只报告出生体重是死亡风险因素的母亲的研究支持这一概念。虽然NCD的病因尚不清楚，但巴里布伦纳解释了低出生体重儿童肾小球数量（nGlom）低的概念，随后根据盖顿的肾脏生理学研究进展，将高滤过作为成人HT和CKD的病理生理学病因。几个种族群体的尸检显示了胎儿和成人肾脏的解剖病理学证据。由于肾储备，在体内证明肾功能与肾体积的比例在成人中更困难。这些理论的最大影响可以在儿科和产科实践中看到。
According to studies undertaken over the past 40 years, low birthweight (LBW) is not only a significant predictor of perinatal death and morbidity, but also increases the risk of chronic non-communicable diseases (NCDs) in adulthood. The purpose of this paper is to summarize the research on LBW as a risk factor for NCDs in adults. The Barker hypothesis was based on the finding that adults with an LBW or an unhealthy intrauterine environment, as well as a rapid catch-up, die due to NCDs. Over the last few decades, terminology such as thrifty genes, fetal programming, developmental origins of health and disease (DOHaD), and epigenetic factors have been coined. The most common NCDs include cardiovascular disease, diabetes mellitus type 2 (DMT2), hypertension (HT), dyslipidemia, proteinuria, and chronic kidney disease (CKD). Studies in mothers who experienced famine and those that solely reported birth weight as a risk factor for mortality support the concept. Although the etiology of NCD is unknown, Barry Brenner explained the notion of a low glomerular number (nGlom) in LBW children, followed by the progression to hyperfiltration as the physiopathologic etiology of HT and CKD in adults based on Guyton's renal physiology work. Autopsies of several ethnic groups have revealed anatomopathologic evidence in fetuses and adult kidneys. Because of the renal reserve, demonstrating renal function in proportion to renal volume in vivo is more difficult in adults. The greatest impact of these theories can be seen in pediatrics and obstetrics practice.
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DOI：
10.1136/adc.67.4_spec_no.357
发表时间：
1992-04-01
影响因子：
4.4
作者：
HAWDON, JM;PLATT, MPW;AYNSLEYGREEN, A
通讯作者：
AYNSLEYGREEN, A
影响因子：
3
作者：
Abitbol, Carolyn L.;Chandar, Jayanthi;Zilleruelo, Gaston
通讯作者：
Zilleruelo, Gaston
影响因子：
7.3
作者：
DUNNILL M S;HALLEY W
通讯作者：
HALLEY W
影响因子：
8.3
作者：
Golic, Michaela;Stojanovska, Violeta;Dechend, Ralf
通讯作者：
Dechend, Ralf
影响因子：
7.7
作者：
Evans, David M.;Moen, Gunn-Helen;Warrington, Nicole M.
通讯作者：
Warrington, Nicole M.