Abscisic acid-mediated epigenetic processes in plant development and stress responses.
Abscisic acid-mediated epigenetic processes in plant development and stress responses.
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DOI：
10.1111/j.1744-7909.2008.00727.x
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发表时间：
2008-10
影响因子：
11.4
通讯作者：
Zhu JK
中科院分区：
文献类型：
--
作者：
Chinnusamy V;Gong Z;Zhu JK
脱甲酸（ABA）调节在非应激条件下的植物过程，生长和发育，并在非生物胁迫耐受性中起关键作用。尽管ABA调节的遗传过程是众所周知的，但最近的发现表明表观遗传过程是ABA调节过程不可或缺的一部分。表观遗传机制，即组蛋白的修饰和胞嘧啶DNA甲基化诱导的基因组的修饰会导致表观遗传学，这为生物体的基因组增加了多样性和复杂性。组蛋白单泛素化似乎通过组蛋白H2B单泛素化来调节种子中的ABA水平。 ABA和H2B泛素化依赖性染色质重塑调节种子休眠。种子成熟所需的转录因子网络通过组蛋白脱乙酰基酶（HDAC）依赖性和泡菜染色质重塑复合物（CRC）抑制，而ABA直接或通过抑制HDAC诱导这些基因的表达。非生物应力诱导的ABA通过HDACS和HOS15依赖性组蛋白脱乙酰化以及通过ATP依赖性开关/蔗糖非发酵CRC调节了气孔反应和应力响应基因表达。 ABA还可能通过DNA甲基化和短干扰RNA途径来调节非生物应力反应。关于ABA调节的表观基因组的进一步研究将非常有用，以了解植物的发育，压力适应和压力记忆。
Abscisic acid (ABA) regulates diverse plant processes, growth and development under non-stress conditions and plays a pivotal role in abiotic stress tolerance. Although ABA-regulated genetic processes are well known, recent discoveries reveal that epigenetic processes are an integral part of ABA-regulated processes. Epigenetic mechanisms, namely, histone modifications and cytosine DNA methylation-induced modification of genome give rise to epigenomes, which add diversity and complexity to the genome of organisms. Histone monoubiquitination appears to regulate ABA levels in developing seeds through histone H2B monoubiquitination. ABA and H2B ubiquitination dependent chromatin remodeling regulate seed dormancy. Transcription factor networks necessary for seed maturation are repressed by histone deacetylases (HDACs)-dependent and PICKLE chromatin remodeling complexes (CRCs), whereas ABA induces the expression of these genes directly or through repression of HDACs. Abiotic stress-induced ABA regulates stomatal response and stress-responsive gene expression through HDACs and HOS15-dependent histone deacetylation, as well as through the ATP-dependent SWITCH/SUCROSE NONFERMENTING CRC. ABA also probably regulates the abiotic stress response through DNA methylation and short interfering RNA pathways. Further studies on ABA-regulated epigenome will be of immense use to understand the plant development, stress adaptation and stress memory.
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DOI：
10.1073/pnas.0603563103
发表时间：
2006-08-01
影响因子：
11.1
作者：
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作者：
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影响因子：
6.9
作者：
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通讯作者：
Zhu, JK
DOI：
10.1016/j.bbrc.2007.03.010
发表时间：
2007-05-18
影响因子：
3.1
作者：
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