Long noncoding RNA-based chromatin control of germ cell differentiation: a yeast perspective.

Long noncoding RNA-based chromatin control of germ cell differentiation: a yeast perspective.
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DOI:
10.1007/s10577-013-9393-5
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发表时间:
2013-12
影响因子:
2.6
通讯作者:
Verdel, Andre
Verdel, Andre
中科院分区:
生物学2区
文献类型:
--
作者:
Hiriart, Edwige;Verdel, Andre

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生殖细胞分化是二倍体祖细胞通过减数分裂产生单倍体细胞的细胞过程,从单细胞酵母到哺乳动物都是保守的。近年来,酵母生殖细胞分化过程已被证明是一个强大的生物系统,以确定和研究几个长的非编码RNA(lncRNA),发挥核心作用,直接作用于染色质的细胞分化的调控。值得注意的是,在研究充分的芽殖酵母酿酒酵母和裂殖酵母粟酒裂殖酵母中,生殖细胞分化的基于lncRNA的染色质调节是完全不同的。本文通过对S. cerevisiae和S.粟酒这些基于lncRNA的染色质调节的一部分可能在其他真核生物中是保守的,并且在生殖细胞分化的背景下或更普遍地在多细胞生物体的发育中发挥关键作用。
Germ cell differentiation, the cellular process by which a diploid progenitor cell produces by meiotic divisions haploid cells, is conserved from the unicellular yeasts to mammals. Over the recent years, yeast germ cell differentiation process has proven to be a powerful biological system to identify and study several long noncoding RNAs (lncRNAs) that play a central role in regulating cellular differentiation by acting directly on chromatin. Remarkably, in the well-studied budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe, the lncRNA-based chromatin regulations of germ cell differentiation are quite different. In this review, we present an overview of these regulations by focusing on the mechanisms and their respective functions both in S. cerevisiae and in S. pombe. Part of these lncRNA-based chromatin regulations may be conserved in other eukaryotes and play critical roles either in the context of germ cell differentiation or, more generally, in the development of multicellular organisms.
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