Pro-Inflammatory Cytokines in the Formation of the Pre-Metastatic Niche.
Pro-Inflammatory Cytokines in the Formation of the Pre-Metastatic Niche.
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DOI：
10.3390/cancers12123752
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发表时间：
2020-12-13
期刊：
影响因子：
5.2
通讯作者：
Lin J
中科院分区：
文献类型：
--
作者：
Li R;Wen A;Lin J
转移前生态位的形成是肿瘤转移的关键，转移前的生态位是远离原发肿瘤的器官的有利微环境。我们回顾了一个关键的参与者，一类由肿瘤细胞和组织中的其他细胞分泌的名为促炎细胞因子的蛋白质，在帮助建立转移前生态位中所起的作用。针对促炎细胞因子的各种药物已经开发出来，它们对肿瘤转移的影响正在调查中。未来的临床研究应该集中于将这些药物结合起来，并在癌症手术中应用它们，这是建立转移前利基的关键时刻。在原发肿瘤存在的情况下，转移前的生态位建立在次级器官中，作为后续肿瘤转移的有利微环境。这个过程是由骨髓来源的细胞、原发肿瘤来源的因子和细胞外基质来协调的。本文根据最新研究，综述了IL-6、IL-1β、CC-趋化因子配体2、粒细胞集落刺激因子、粒细胞-巨噬细胞集落刺激因子、基质细胞衍生因子-1、巨噬细胞移动抑制因子和趋化因子配体1等促炎细胞因子在肿瘤转移前生态位形成中的作用。肿瘤细胞或基质细胞释放的促炎性细胞因子以自分泌和旁分泌方式诱导肿瘤细胞表型改变，募集骨髓源性细胞，形成炎症环境，为转移细胞定植提供次级器官的微环境。考虑到促炎细胞因子在生态位形成中的积极参与，针对它们的临床策略提供了抑制转移前生态位建立的方法，从而减缓了转移进展。我们回顾了针对转移性癌症患者不同炎性细胞因子的临床试验。由于促炎细胞因子的多效性和冗余性，未来应设计联合治疗。
The formation of the pre-metastatic niche, a favorable microenvironment in an organ distant from a primary tumor, is critical for tumor metastasis. We review the role of a key player, a class of proteins named pro-inflammatory cytokines secreted from both tumor cells and other cells in tissues, in helping to build the pre-metastatic niche. Various drugs have been developed to target pro-inflammatory cytokines, and their effects on tumor metastases are under investigation. Future clinical studies should focus on combining those drugs and applying them during cancer surgery, a critical moment for the establishment of the pre-metastatic niche. In the presence of a primary tumor, the pre-metastatic niche is established in secondary organs as a favorable microenvironment for subsequent tumor metastases. This process is orchestrated by bone marrow-derived cells, primary tumor-derived factors, and extracellular matrix. In this review, we summarize the role of pro-inflammatory cytokines including interleukin (IL)-6, IL-1β, CC-chemokine ligand 2 (CCL2), granulocyte-colony stimulating factor (G-CSF), granulocyte–macrophage colony-stimulating factor (GM-CSF), stromal cell-derived factor (SDF)-1, macrophage migration inhibitory factor (MIF), and Chemokine (C–X–C motif) ligand 1 (CXCL1) in the formation of the pre-metastatic niche according to the most recent studies. Pro-inflammatory cytokines released from tumor cells or stromal cells act in both autocrine and paracrine manners to induce phenotype changes in tumor cells, recruit bone marrow-derived cells, and form an inflammatory milieu, all of which prime a secondary organ’s microenvironment for metastatic cell colonization. Considering the active involvement of pro-inflammatory cytokines in niche formation, clinical strategies targeting them offer ways to inhibit the establishment of the pre-metastatic niche and therefore attenuate metastatic progression. We review clinical trials targeting different inflammatory cytokines in patients with metastatic cancers. Due to the pleiotropy and redundancy of pro-inflammatory cytokines, combined therapies should be designed in the future.
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影响因子：
4.8
作者：
Chang, Qing;Bournazou, Eirini;Bromberg, Jacqueline
通讯作者：
Bromberg, Jacqueline
影响因子：
50.3
作者：
Granot Z;Henke E;Comen EA;King TA;Norton L;Benezra R
通讯作者：
Benezra R
影响因子：
5.6
作者：
Bent R;Moll L;Grabbe S;Bros M
通讯作者：
Bros M
影响因子：
8.7
作者：
Dinarello CA
通讯作者：
Dinarello CA
DOI：
10.1038/s41577-019-0131-x
发表时间：
2019-04
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Altan-Bonnet G;Mukherjee R
通讯作者：
Mukherjee R