Bioactive TGF-beta can associate with lipoproteins and is enriched in those containing apolipoprotein E3.
Bioactive TGF-beta can associate with lipoproteins and is enriched in those containing apolipoprotein E3.
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DOI：
10.1111/j.1471-4159.2009.06222.x
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发表时间：
2009-08
影响因子：
4.7
通讯作者：
Wyss-Coray T
中科院分区：
文献类型：
--
作者：
Tesseur I;Zhang H;Brecht W;Corn J;Gong JS;Yanagisawa K;Michikawa M;Weisgraber K;Huang Y;Wyss-Coray T
Transforming growth factor-β1 (TGF-β1) has central functions in development, tissue maintenance, and repair and has been implicated in major diseases. We discovered that TGF-β1 contains several amphipathic helices and hydrophobic domains similar to apolipoprotein E (apoE), a protein involved in lipoprotein metabolism. Indeed, TGF-β1 associates with lipoproteins isolated from human plasma, cultured liver cells, or astrocytes, and its bioactivity was highest in high-density lipoprotein (HDL) preparations. Importantly, lipoproteins containing the apoE3 isoform had higher TGF-β levels and bioactivity than those containing apoE4, a major genetic risk factor for atherosclerosis and Alzheimer’s disease. Because TGF-β1 can be protective in these diseases an association with apoE3 may be beneficial. Association of TGF-β with different types of lipoproteins may facilitate its diffusion, regulate signaling, and offer additional specificity for this important growth factor.
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影响因子：
56.9
作者：
MAHLEY, RW
通讯作者：
MAHLEY, RW
影响因子：
5.3
作者：
Raber, J;Bongers, G;Mucke, L
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影响因子：
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作者：
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DOI：
10.1073/pnas.90.5.1977
发表时间：
1993-03-01
影响因子：
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作者：
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通讯作者：
ROSES, AD
影响因子：
2.9
作者：
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通讯作者：
Flanders, KC