3B but which 3B and that's just one of the questions: the heterogeneity of human 5-HT3 receptors.
3B but which 3B and that's just one of the questions: the heterogeneity of human 5-HT3 receptors.
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DOI：
10.1016/j.tips.2008.06.001
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发表时间：
2008-09
影响因子：
13.8
通讯作者：
Krzywkowski K
中科院分区：
文献类型：
--
作者：
Jensen AA;Davies PA;Bräuner-Osborne H;Krzywkowski K
5-羟色胺3（5-HT 3）受体在中枢和外周神经系统中广泛表达，在中枢和外周神经系统中它介导或调节广泛的生理过程。该受体被用于治疗恶心和/或呕吐和肠易激综合征的药物靶向，并已被提议作为各种精神疾病的潜在药物靶点。5-HT 3受体是一种五聚体配体门控离子通道，属于Cys环受体家族。与表征其他Cys环受体的巨大异质性相反，天然5-HT 3受体历史上被认为是更同质的受体群体。然而，最近发现的额外的5-HT 3亚基和曙光意识到，中央和外周5-HT 3受体群体可能包括几个亚型，其特征在于不同的功能特性强调了人类5-HT 3受体信号的复杂性。在这篇评论中，这些研究结果的潜在影响和全新的层的个体间的多样性引入5-HT 3受体系统的遗传变异将被概述。
The 5-hydroxytryptamine 3 (5-HT3) receptor is expressed widely in the central and peripheral nervous systems, where it mediates or modulates a wide range of physiological processes. The receptor is targeted by drugs administered for nausea and/or emesis and irritable bowel syndrome and has been proposed as a potential drug target in various psychiatric disorders. The 5-HT3 receptor is a pentameric ligand-gated ion channel and belongs to the Cys-loop receptor family. In contrast to the immense heterogeneity characterizing other Cys-loop receptors, native 5-HT3 receptors historically have been considered a much more homogenous receptor population. However, the recent discovery of additional 5-HT3 subunits and the dawning realization that central and peripheral 5-HT3 receptor populations might comprise several subtypes characterized by distinct functional properties has emphasized the complexity of human 5-HT3 receptor signaling. In this review potential implications of these findings and of the entirely new layer of interindividual diversity introduced to the 5-HT3 receptor system by genetic variations will be outlined.
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影响因子：
13.8
作者：
Fletcher, S;Barnes, NM
通讯作者：
Barnes, NM
影响因子：
2.6
作者：
Krzywkowski, Karen;Jensen, Anders A.;Brauner-Osborne, Hans
通讯作者：
Brauner-Osborne, Hans
影响因子：
3.9
作者：
Krzywkowski, K.
通讯作者：
Krzywkowski, K.
影响因子：
3.6
作者：
Brüss, M;Barann, M;Bönisch, H
通讯作者：
Bönisch, H
影响因子：
2.5
作者：
JONES, KA;SURPRENANT, A
通讯作者：
SURPRENANT, A