Multifunctional oxygen-enriching nano-theranostics for cancer-specific magnetic resonance imaging and enhanced photodynamic/photothermal therapy
Multifunctional oxygen-enriching nano-theranostics for cancer-specific magnetic resonance imaging and enhanced photodynamic/photothermal therapy
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用于癌症特异性磁共振成像和增强光动力/光热治疗的多功能富氧纳米治疗学
DOI：
10.1007/s12274-020-2646-7
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发表时间：
2020-01
期刊：
影响因子：
9.9
通讯作者：
Wong Chun-Yuen
中科院分区：
文献类型：
--
作者：
Zhang Li;Yang Zhe;Ren Jinghua;Ba Li;He Wenshan;Wong Chun-Yuen
近年来，光动力疗法（PDT）和光热疗法（PTT）的联合应用引起了人们极大的兴趣，但光敏剂的非特异性分布和肿瘤固有的缺氧微环境一直限制着其治疗效率。我们在此报告了一种纳米治疗诊断系统，表示为Ce6-CuS/MSN@PDA@MnO2-FA NPs，其结合了PDT，PTT，磁共振（MR）成像与缺氧缓解和肿瘤靶向功能。该设计的核心是使用贻贝启发的聚多巴胺（PDA）涂层来封装二氢卟酚e6（Ce6）和硫化铜纳米颗粒（CuS NP）负载的介孔二氧化硅纳米颗粒（MSN）核。PDA涂层不仅充当pH敏感性看门人以防止Ce6在非酸性肿瘤微环境（TME）下过早释放，而且有利于后功能化，使缓解缺氧的MnO 2纳米片和肿瘤靶向配体叶酸-PEG-硫醇（FA-PEG-SH）可以被修饰在药物系统的外部。体外和体内试验清楚地表明，所有这些功能协同工作，预期该系统具有较低的暗细胞毒性，在660 nm/808 nm激光照射下，可被4T1细胞有效地内化并使细胞活力降低至2%。经PDT/PTT联合治疗，4T1荷瘤小鼠的肿瘤在2周内几乎完全被破坏。连同所展示的TME敏感的MR成像性能，Ce6-CuS/MSN@PDA@MnO2-FA NPs代表了一种多功能原型，具有开发成临床治疗诊断学的巨大潜力。
The combination of photodynamic therapy (PDT) and photothermal therapy (PTT) has attracted much interest in recent years, but non-specific distribution of photosensitizers and intrinsic tumor hypoxic microenvironment have continued to limit its therapeutic efficiency. We herein report a nano-theranostic system, denoted as Ce6-CuS/MSN@PDA@MnO2-FA NPs, which combines PDT, PTT, magnetic resonance (MR) imaging with hypoxia-relieving and tumor-targeting functionalities. Central to this design is the use of mussel-inspired polydopamine (PDA) coating to encapsulate the chlorin e6 (Ce6) and copper sulfide nanoparticles (CuS NPs) loaded mesoporous silica nanoparticle (MSN) core. The PDA coating not only acts as pH sensitive gatekeeper to prevent the premature release of Ce6 under non-acidic tumor microenvironment (TME), but also facilitates post-functionalization so that hypoxia-relieving MnO2nano-sheets and tumor-targeting ligand folic acid-PEG-thiol (FA-PEG-SH) can be decorated on the outer part of the drug system.In vitroandin vivomeasurements clearly demonstrated that all these functionalities worked synergistically as expected. The system, having a low dark cytotoxicity, can be effectively internalized by 4T1 cells and decrease the cell viability to 2% upon 660 nm/808 nm laser irradiation. Tumors in 4T1 tumor-bearing mice can almost be completely destroyed in 2 weeks via combined PDT/PTT. Together with the TME-sensitive MR imaging performance demonstrated, Ce6-CuS/MSN@PDA@MnO2-FA NPs represent a multifunctional prototype which holds great potential to be developed into clinical theranostics.
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DOI：
10.1002/advs.201600540
发表时间：
2017-08
期刊：
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
影响因子：
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