Activated protein C in epilepsy pathophysiology.
Activated protein C in epilepsy pathophysiology.
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DOI：
10.3389/fnins.2023.1251017
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发表时间：
2023
影响因子：
4.3
通讯作者：
Li, Ji
中科院分区：
文献类型：
--
作者：
Zoungrana, Linda Ines;Didik, Steven;Wang, Hao;Slotabec, Lily;Li, Ji
癫痫是最常见的神经系统疾病之一，其特征在于反复发作，并且根据发作的类型，它可能导致严重的结果。癫痫的发展机制尚未完全了解，但这种疾病的一些共同特征是血脑屏障破坏，小胶质细胞活化和神经炎症。这些也是活化蛋白C（APC）的靶点。事实上，通过下调凝血酶（称为促炎因子），APC起到抗炎作用。APC也是一种抗凋亡蛋白，例如通过阻断p53介导的凋亡。APC的神经保护作用可能是通过作用于内皮细胞来防止血脑屏障功能障碍。此外，通过下调促凋亡基因和促炎基因，APC的神经保护作用可以减少效应或预防癫痫发病。APC的活性作用于血脑屏障破坏、炎症和细胞凋亡，并引起神经发生，所有这些标志都可能潜在地治疗或预防癫痫。本文就活化蛋白C与癫痫的发病机制、功能以及两者之间的可能联系作一综述。
Epilepsy is one of the most common neurologic disorders that is characterized by recurrent seizures, and depending on the type of seizure, it could lead to a severe outcome. Epilepsy’s mechanism of development is not fully understood yet, but some of the common features of the disease are blood-brain barrier disruption, microglia activation, and neuroinflammation. Those are also targets of activated protein C (APC). In fact, by downregulating thrombin, known as a pro-inflammatory, APC acts as an anti-inflammatory. APC is also an anti-apoptotic protein, instance by blocking p53-mediated apoptosis. APC’s neuroprotective effect could prevent blood-brain barrier dysfunction by acting on endothelial cells. Furthermore, through the downregulation of proapoptotic, and proinflammatory genes, APC’s neuroprotection could reduce the effect or prevent epilepsy pathogenesis. APC’s activity acts on blood-brain barrier disruption, inflammation, and apoptosis and causes neurogenesis, all hallmarks that could potentially treat or prevent epilepsy. Here we review both Activated Protein C and epilepsy mechanism, function, and the possible association between them.
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