Effects of pramipexole on the reinforcing effectiveness of stimuli that were previously paired with cocaine reinforcement in rats.
Effects of pramipexole on the reinforcing effectiveness of stimuli that were previously paired with cocaine reinforcement in rats.
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DOI：
10.1007/s00213-011-2382-5
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发表时间：
2012-01
影响因子：
3.4
通讯作者：
Woods, James H.
中科院分区：
文献类型：
--
作者：
Collins, Gregory T.;Cunningham, Alyssa R.;Chen, Jianyong;Wang, Shaomeng;Newman, Amy H.;Woods, James H.
在实验动物中，类多巴胺D2激动剂在替代可卡因时维持反应。然而，这些效应似乎是通过与以前与可卡因强化(CS)配对的刺激相互作用而调节的。评估可卡因配对刺激对普拉克索维持和诱导反应的影响程度。训练大鼠在固定比率1(FR1)或递增比率(PR)强化计划下进行鼻戳可卡因。在接受FR1训练的大鼠中，普拉克索被用来替代可卡因，要么配对注射CS，要么在没有注射的情况下注射。评价受试者给予普拉克索对CS递呈诱导FR1和PR反应的能力。改变刺激条件以及D2受体拮抗剂(L-741,626)和D3受体拮抗剂(PG01037)对普拉克索PR反应的影响。当替代可卡因时，当注射与CS配对时，普拉克索保持较高的应答率，但当省略CS时，保持较低的应答率。类似地，实验者使用普拉克索引起FR1或PR反应的剂量依赖性增加，当呈现CS时，观察到高响应率，而当省略CS呈现时，响应率低。D2和D3拮抗剂对普拉克索的PR效应有不同的影响，L-741、626和PG01037对CS维持效应的量效曲线分别右移和下移。这些数据表明，普拉克索能够增强条件刺激的强化效果，并增加了类似机制导致接受普拉克索治疗的患者冲动控制障碍发生率增加的可能性。
Dopamine D2-like agonists maintain responding when substituted for cocaine in laboratory animals. However, these effects appear to be mediated by an interaction with stimuli that were previously paired with cocaine reinforcement (CS). To evaluate the extent to which the pramipexole-maintained and -induced responding are influenced by cocaine-paired stimuli. Rats were trained to nosepoke for cocaine under fixed ratio 1 (FR1) or progressive ratio (PR) schedules of reinforcement. In FR1-trained rats, pramipexole was substituted for cocaine with injections either paired with CSs, or delivered in their absence. The capacity of experimenter-administered pramipexole to induce FR1 and PR responding for CS presentation was evaluated. The effects of altering stimulus conditions, as well as pretreatments with D2- (L-741,626) and D3-preferring (PG01037) antagonists on pramipexole-induced PR responding were also evaluated. When substituted for cocaine, pramipexole maintained responding at high rates when injections were paired with CSs, but low rates when CSs were omitted. Similarly, experimenter-administered pramipexole induced dose-dependent increases in FR1 or PR responding, with high rates of responding observed when the CS was presented, and low rates of responding when CS presentation was omitted. D2 and D3 antagonists differentially affected pramipexole-induced PR responding, with L-741,626 and PG01037 producing rightward, and downward shifts in the dose-response curve for CS-maintained responding, respectively. These data indicate that pramipexole is capable of enhancing the reinforcing effectiveness of conditioned stimuli, and raise the possibility that similar mechanisms are responsible for the increased occurrence of impulse control disorders in patients being treated with pramipexole.
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影响因子：
7.6
作者：
Di Ciano, P;Underwood, RJ;Everitt, BJ
通讯作者：
Everitt, BJ
影响因子：
3.4
作者：
Boulougouris, Vasileios;Castane, Anna;Robbins, Trevor W.
通讯作者：
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影响因子：
2.9
作者：
Hamidovic, Ajna;Kang, Un Jung;de Wit, Harriet
通讯作者：
de Wit, Harriet
影响因子：
3.4
作者：
Haney, M;Foltin, RW;Fischman, MW
通讯作者：
Fischman, MW
DOI：
10.1124/jpet.107.123042
发表时间：
2007-11-01
影响因子：
3.5
作者：
Collins, Gregory T.;Woods, James H.
通讯作者：
Woods, James H.