Quantitative Assessments of Mechanical Responses upon Radial Extracorporeal Shock Wave Therapy.
Quantitative Assessments of Mechanical Responses upon Radial Extracorporeal Shock Wave Therapy.
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径向体外冲击波疗法机械反应的定量评估
DOI：
10.1002/advs.201700797
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Hu G
中科院分区：
文献类型：
--
作者：
Liu Y;Chen X;Guo A;Liu S;Hu G
尽管径向体外冲击波治疗（rESWT）已广泛用于治疗骨科疾病，并取得了良好的临床效果，但rESWT在很大程度上依赖于临床医生的个人经验和任意判断，而不知道靶部位的给药剂量与有效剂量之间的关系。事实上，从业者缺乏一种通用且可靠的方法来定量评估生物组织内压力波的传播和分布。本研究开发了一种方法，结合联合收割机的实验测量和计算模拟，通过校准和验证计算模型与实验测量，从rESWT获得压力场。通过粘贴和植入柔性膜传感器，分别测量了培养皿底部和生物组织内部的波压力。详细的波浪动力学模拟通过显式有限元分析。这些数据表明，来自rESWT的波是定向辐射的，并且可以被建模为从振动的圆形活塞产生的声波。因此，建立模型，以关联在培养皿的底部和在生物组织的轴向方向上的压力振幅。此外，针对人体腰椎的rESWT的试点模拟显示了详细且真实的压力场映射。本研究为rESWT的个体化治疗方案和机制研究开辟了新的途径。
Although radial extracorporeal shock wave therapy (rESWT) has been widely used to treat orthopedic disorders with promising clinical results, rESWT largely relies on clinicians' personal experiences and arbitrary judgments, without knowing relationships between administration doses and effective doses at target sites. In fact, practitioners lack a general and reliable way to assess propagation and distribution of pressure waves inside biological tissues quantitatively. This study develops a methodology to combine experimental measurements and computational simulations to obtain pressure fields from rESWT through calibrating and validating computational models with experimental measurements. Wave pressures at the bottom of a petri dish and inside biological tissues are measured, respectively, by attaching and implanting flexible membrane sensors. Detailed wave dynamics are simulated through explicit finite element analyses. The data decipher that waves from rESWT radiate directionally and can be modeled as acoustic waves generated from a vibrating circular piston. Models are thus established to correlate pressure amplitudes at the bottom of petri dishes and in the axial direction of biological tissues. Additionally, a pilot simulation upon rESWT for human lumbar reveals a detailed and realistic pressure field mapping. This study will open a new avenue of personalized treatment planning and mechanism research for rESWT.
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