Pericyte-endothelial crosstalk: implications and opportunities for advanced cellular therapies.
Pericyte-endothelial crosstalk: implications and opportunities for advanced cellular therapies.
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DOI：
10.1016/j.trsl.2014.01.011
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发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
Herman IM
中科院分区：
文献类型：
--
作者：
Geevarghese A;Herman IM
周细胞是微循环的壁细胞，其已被证明在调节微血管形态发生和稳定性中起关键作用，遍及所评估的每个组织床和器官系统。重要的是，最近的工作表明，周细胞与间充质和脂肪来源的干细胞有几个共同的特征，这表明在真正的周细胞和这些血管“祖细胞”之间可能存在谱系相关的连接，这些血管“祖细胞”可以与内皮细胞一起占据血管周围的位置。因此，作为血管重塑介质的周细胞身份可能被其与其祖细胞或多能细胞对应物的密切关系所混淆，但仍证明其作为未满足的临床需求的基于细胞的疗法的潜在效用。对这种疗法的发展至关重要的是全面了解调节这些相关细胞类型的起源和命运，以及揭示周细胞和内皮细胞沟通的分子机制。这种机制的输入，破坏正常的细胞“串扰”在疾病的发病和进展，提供了干预的机会，并将在血管病变伴随肿瘤生长，糖尿病和纤维化的背景下进行讨论。
Pericytes are mural cells of the microcirculation, which have been shown to play key roles in regulating microvascular morphogenesis and stability, throughout each tissue bed and organ system assessed. Importantly, recent work has revealed that pericytes share several characteristics with mesenchymally- and adipose-derived stem cells suggesting that there may be lineage-related connections amongst bonafide pericytes and these vascular ‘progenitors,’ which can assume a perivascular position in association with endothelial cells. Hence, pericyte identity as a mediator of vascular remodeling may be confounded by its close relationships with its progenitors or pluripotent cell counterparts and yet demonstrates their potential utility as cell-based therapies for unmet clinical needs. Crucial to the development of such therapies will be a comprehensive understanding of the origin and fate regulating these related cell types as well as the unveiling of the molecular mechanisms by which pericytes and endothelial cells communicate. Such mechanistic inputs, which disrupt normal cellular ‘cross-talk’ during disease inception and progression, offer opportunities for intervention and will be discussed in the context of the vasculopathies accompanying tumor growth, diabetes, and fibrosis.
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影响因子：
5.3
作者：
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通讯作者：
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DOI：
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发表时间：
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作者：
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通讯作者：
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