Cohort profile: early school years follow-up of the Asking Questions about Alcohol in Pregnancy Longitudinal Study in Melbourne, Australia (AQUA at 6).
Cohort profile: early school years follow-up of the Asking Questions about Alcohol in Pregnancy Longitudinal Study in Melbourne, Australia (AQUA at 6).
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DOI：
10.1136/bmjopen-2021-054706
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发表时间：
2022-01-17
期刊：
影响因子：
2.9
通讯作者：
Anderson PJ
中科院分区：
文献类型：
--
作者：
Muggli E;Halliday J;Elliott EJ;Penington A;Thompson D;Spittle AJ;Forster D;Lewis S;Hearps S;Anderson PJ
关于怀孕期间酒精的提问（AQUA）研究成立于2011年，是一项由1570对母子组成的出生前队列研究，旨在评估产前低至中度酒精暴露和零星酗酒对儿童长期发育的影响。在澳大利亚墨尔本的公立医院接受一般产前检查的妇女在怀孕的头三个月被招募，在怀孕期间和产后12个月和24个月被随访三次。目前对6-8岁儿童的随访旨在加强我们对产前酒精暴露水平与神经心理功能，面部畸形，大脑结构和功能之间关系的理解。在2018年6月至2021年4月期间，1342个符合条件的AQUA研究家庭中有802个完成了父母报告问卷（60%）。与COVID-19大流行相关的限制中断了招募，但对696名儿童（52%）进行了早期学龄神经心理学评估，并收集了482张（36%）颅面图像。一个预先计划的，具有代表性的146名儿童的子集完成了脑部MRI。现有的生物样本库通过收集427（32%）儿童口腔拭子进行扩展。超过一半（59%）的母亲在怀孕期间饮酒，五分之一的母亲在怀孕前至少有一次酗酒事件。儿童的颅面形状在12个月大时进行了检查，低至中度的产前酒精暴露与微妙的面中部变化有关。在2岁时，正式的发育评估显示没有证据表明认知、语言或运动结果与任何暴露水平相关。我们将研究产前酒精暴露与6-8岁时神经发育特定方面的关系，包括颅面形状，大脑结构和功能。遗传学和表观遗传学对结果个体差异的贡献将与国家和国际合作一起进行检查。
The Asking Questions about Alcohol in Pregnancy (AQUA) study, established in 2011, is a prebirth cohort of 1570 mother and child pairs designed to assess the effects of low to moderate prenatal alcohol exposure and sporadic binge drinking on long-term child development. Women attending general antenatal clinics in public hospitals in Melbourne, Australia, were recruited in their first trimester, followed up three times during pregnancy and at 12 and 24 months postpartum. The current follow-up of the 6–8-year-old children aims to strengthen our understanding of the relationship between these levels of prenatal alcohol exposure and neuropsychological functioning, facial dysmorphology, brain structure and function. Between June 2018 and April 2021, 802 of the 1342 eligible AQUA study families completed a parent-report questionnaire (60%). Restrictions associated with COVID-19 pandemic disrupted recruitment, but early school-age neuropsychological assessments were undertaken with 696 children (52%), and 482 (36%) craniofacial images were collected. A preplanned, exposure-representative subset of 146 children completed a brain MRI. An existing biobank was extended through collection of 427 (32%) child buccal swabs. Over half (59%) of mothers consumed some alcohol during pregnancy, with one in five reporting at least one binge-drinking episode prior to pregnancy recognition. Children’s craniofacial shape was examined at 12 months of age, and low to moderate prenatal alcohol exposure was associated with subtle midface changes. At 2 years of age, formal developmental assessments showed no evidence that cognitive, language or motor outcome was associated with any of exposure level. We will investigate the relationship between prenatal alcohol exposure and specific aspects of neurodevelopment at 6–8 years, including craniofacial shape, brain structure and function. The contribution of genetics and epigenetics to individual variation in outcomes will be examined in conjunction with national and international collaborations.
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影响因子：
5.8
作者：
Lebel, Catherine;Roussotte, Florence;Sowell, Elizabeth R.
通讯作者：
Sowell, Elizabeth R.
DOI：
10.1097/01.alc.0000164374.32229.a2
发表时间：
2005-05-01
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
Dawson, DA;Grant, BF;Zhou, Y
通讯作者：
Zhou, Y
DOI：
10.1176/appi.ajp.2020.20010086
发表时间：
2020-11-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Lees B;Mewton L;Jacobus J;Valadez EA;Stapinski LA;Teesson M;Tapert SF;Squeglia LM
通讯作者：
Squeglia LM
影响因子：
3
作者：
Lakes, Kimberley D.;Swanson, James M.;Riggs, Matt
通讯作者：
Riggs, Matt
影响因子：
8
作者：
Hoyme, H. Eugene;Kalberg, Wendy O.;May, Philip A.
通讯作者：
May, Philip A.