Imaging the impact of prenatal alcohol exposure on the structure of the developing human brain.
Imaging the impact of prenatal alcohol exposure on the structure of the developing human brain.
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DOI：
10.1007/s11065-011-9163-0
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发表时间：
2011-06
影响因子：
5.8
通讯作者：
Sowell, Elizabeth R.
中科院分区：
文献类型：
--
作者：
Lebel, Catherine;Roussotte, Florence;Sowell, Elizabeth R.
关键词：
产前接触酒精会对发育中的大脑产生多种影响，包括对选择性大脑结构的损害。我们回顾了关于产前接触酒精的受试者大脑异常的结构磁共振成像 (MRI) 研究。最常见的发现包括脑容量减少和胼胝体畸形。先进的方法已经能够检测多个大脑区域的形状、厚度和位移变化。酒精的致畸作用似乎很广泛，几乎影响整个大脑。唯一相对幸免的区域是枕叶。最近的研究将认知与酒精暴露对象的潜在大脑结构联系起来，并且一些报告报告了大脑损伤严重程度的模式，因为它与面部畸形或酒精暴露程度有关。未来研究探索大脑结构、认知测量、畸形、年龄和其他变量之间的关系，对于进一步理解产前酒精暴露的巨大影响和评估可能的干预措施将是有价值的。
Prenatal alcohol exposure has numerous effects on the developing brain, including damage to selective brain structure. We review structural magnetic resonance imaging (MRI) studies of brain abnormalities in subjects prenatally exposed to alcohol. The most common findings include reduced brain volume and malformations of the corpus callosum. Advanced methods have been able to detect shape, thickness and displacement changes throughout multiple brain regions. The teratogenic effects of alcohol appear to be widespread, affecting almost the entire brain. The only region that appears to be relatively spared is the occipital lobe. More recent studies have linked cognition to the underlying brain structure in alcohol-exposed subjects, and several report patterns in the severity of brain damage as it relates to facial dysmorphology or to extent of alcohol exposure. Future studies exploring relationships between brain structure, cognitive measures, dysmorphology, age, and other variables will be valuable for further comprehending the vast effects of prenatal alcohol exposure and for evaluating possible interventions.
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DOI：
10.1002/ar.b.20114
发表时间：
2006-09-01
期刊：
Anatomical Record Part B:The New Anatomist
影响因子：
--
作者：
Bookstein, Fred L.;Streissguth, Ann P.;Sampson, Paul D.
通讯作者：
Sampson, Paul D.
DOI：
10.1002/tera.1420220110
发表时间：
1980-01-01
期刊：
TERATOLOGY
影响因子：
--
作者：
CHERNOFF, GF
通讯作者：
CHERNOFF, GF
影响因子：
5.7
作者：
Bookstein, FL;Streissguth, AP;Barr, HM
通讯作者：
Barr, HM
影响因子：
2.9
作者：
GILLIAM, DM;STILMAN, A;RILEY, EP
通讯作者：
RILEY, EP
影响因子：
--
作者：
COULTER, CL;LEECH, RW;BRUMBACK, RA
通讯作者：
BRUMBACK, RA