Association of Prenatal Alcohol Exposure With Psychological, Behavioral, and Neurodevelopmental Outcomes in Children From the Adolescent Brain Cognitive Development Study.
Association of Prenatal Alcohol Exposure With Psychological, Behavioral, and Neurodevelopmental Outcomes in Children From the Adolescent Brain Cognitive Development Study.
复制标题
DOI：
10.1176/appi.ajp.2020.20010086
复制
发表时间：
2020-11-01
期刊：
影响因子：
--
通讯作者：
Squeglia LM
中科院分区：
文献类型：
--
作者：
Lees B;Mewton L;Jacobus J;Valadez EA;Stapinski LA;Teesson M;Tapert SF;Squeglia LM
关于宫内轻度至中度酒精暴露对神经发育和相关行为影响的数据有限。这项回顾性调查测试了报告的母亲产前饮酒与未接触物质的青少年的心理、行为和神经发育结果之间的关联。青少年大脑认知发展研究的参与者是 9,719 名青少年（年龄 9.0 至 10.9 岁）。根据家长报告，2,518 人（25.9%）在子宫内曾接触过酒精。广义加性混合模型以及多级横断面和纵向中介模型用于测试产前酒精暴露是否与心理、行为和认知结果相关，以及在控制可能的混杂因素后，大脑结构和静息状态功能连接的差异是否部分解释了基线和一年随访时的这些关联。任何严重程度的产前酒精暴露都与更大的精神病理学、注意力缺陷和冲动相关，其中一些效应显示出剂量依赖性反应。与未接触过酒精的儿童相比，产前接触过酒精的儿童表现出更大的大脑和区域体积以及更大的区域表面积。在子宫内暴露的儿童中，静息态功能连接基本上没有改变。基线和一年随访时的一些心理和行为结果部分可以用在子宫内接触酒精的青少年大脑结构的差异来解释。怀孕期间的任何饮酒都会对儿童产生微妙但显着的心理和行为影响。应继续建议妇女在整个怀孕期间戒酒。
Data on the neurodevelopmental and associated behavioral effects of light to moderate in utero alcohol exposure are limited. This retrospective investigation tested for associations between reported maternal prenatal alcohol use and psychological, behavioral, and neurodevelopmental outcomes in substance-naive youths. Participants were 9,719 youths (ages 9.0 to 10.9 years) from the Adolescent Brain Cognitive Development Study. Based on parental reports, 2,518 (25.9%) had been exposed to alcohol in utero. Generalized additive mixed models and multilevel cross-sectional and longitudinal mediation models were used to test whether prenatal alcohol exposure was associated with psychological, behavioral, and cognitive outcomes, and whether differences in brain structure and resting-state functional connectivity partially explained these associations at baseline and 1-year follow-up, after controlling for possible confounding factors. Prenatal alcohol exposure of any severity was associated with greater psychopathology, attention deficits, and impulsiveness, with some effects showing a dose-dependent response. Children with prenatal alcohol exposure, compared with those without, displayed greater cerebral and regional volume and greater regional surface area. Resting-state functional connectivity was largely unaltered in children with in utero exposure. Some of the psychological and behavioral outcomes at baseline and at the 1-year follow-up were partially explained by differences in brain structure among youths who had been exposed to alcohol in utero. Any alcohol use during pregnancy is associated with subtle yet significant psychological and behavioral effects in children. Women should continue to be advised to abstain from alcohol consumption from conception throughout pregnancy.
登录
查看更多内容
形态学和系统发育特征揭示了中国贵州Samsoniella（虫草科，肉座菌目）的三个新种
影响因子：
3.3
作者：
Chen WH;Han YF;Liang JD;Tian WY;Liang ZQ
通讯作者：
Liang ZQ
DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
5.8
作者：
Lebel, Catherine;Roussotte, Florence;Sowell, Elizabeth R.
通讯作者：
Sowell, Elizabeth R.
影响因子：
4.7
作者：
Hendrickson, Timothy J.;Mueller, Bryon A.;Wozniak, Jeffrey R.
通讯作者：
Wozniak, Jeffrey R.
影响因子：
4.7
作者：
Casey BJ;Cannonier T;Conley MI;Cohen AO;Barch DM;Heitzeg MM;Soules ME;Teslovich T;Dellarco DV;Garavan H;Orr CA;Wager TD;Banich MT;Speer NK;Sutherland MT;Riedel MC;Dick AS;Bjork JM;Thomas KM;Chaarani B;Mejia MH;Hagler DJ Jr;Daniela Cornejo M;Sicat CS;Harms MP;Dosenbach NUF;Rosenberg M;Earl E;Bartsch H;Watts R;Polimeni JR;Kuperman JM;Fair DA;Dale AM;ABCD Imaging Acquisition Workgroup
通讯作者：
ABCD Imaging Acquisition Workgroup