Isolating chemical exchange saturation transfer contrast from magnetization transfer asymmetry under two-frequency rf irradiation.
Isolating chemical exchange saturation transfer contrast from magnetization transfer asymmetry under two-frequency rf irradiation.
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DOI：
10.1016/j.jmr.2011.12.012
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发表时间：
2012-02
影响因子：
2.2
通讯作者：
Jerschow, Alexej
中科院分区：
文献类型：
--
作者：
Lee, Jae-Seung;Regatte, Ravinder R.;Jerschow, Alexej
关键词：
化学交换饱和转移（CEST）是由一般可移动的基团引起的，而磁化转移（MT）是由不移动的质子引起的，近年来在MRI应用中得到了广泛的应用。通常很难将真正的CEST信号与MT效应分开，它们在水共振方面是不对称的。基于Provotorov的饱和理论，建立了磁化转移（MT）的双池模型，并将其推广到双频射频同时辐照的情况。数值模拟和实验结果表明，当两个频率分量都在一个MT池的频谱内时，双频射频辐射可以使MT不对称变得平坦。基于这一结果，我们提出了一种利用双频射频辐射技术分离化学交换饱和转移（CEST）对比和MT不对称对比的策略。
Chemical exchange saturation transfer (CEST), arising from the generally mobile groups, and magnetization transfer (MT) contrast arising from immobile protons, have enjoyed wide popularity recently in MRI applications. It is often difficult to separate genuine CEST signatures from MT effects, which are asymmetric with respect to the water resonance. A two-pool model for magnetization transfer (MT) is established fully based on Provotorov’s theory of saturation, and then extended to the situation of simultaneous two-frequency rf irradiation. Numerical simulations and experimental results demonstrate that two-frequency rf irradiation can flatten out MT asymmetry when both frequency components lie within the spectrum of an MT pool. Based on this result, we propose a strategy to isolate chemical exchange saturation transfer (CEST) contrast from MT asymmetry contrast by using the two-frequency rf irradiation technique.
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