Functional polymorphism -31C/G in the promoter of BIRC5 gene and risk of nasopharyngeal carcinoma among chinese.
Functional polymorphism -31C/G in the promoter of BIRC5 gene and risk of nasopharyngeal carcinoma among chinese.
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DOI：
10.1371/journal.pone.0016748
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发表时间：
2011-02-03
期刊：
影响因子：
3.7
通讯作者：
Zhou G
中科院分区：
文献类型：
--
作者：
Ma F;Zhang H;Zhai Y;Huang W;Zhao C;Ou S;Zhou H;Yuan W;Wang Z;Wang H;Yue W;Yu L;Li P;Xia X;Cai M;Zhang Y;Cui Y;He F;Ma Y;Zhou G
杆状病毒凋亡抑制因子5（Baculoviral inhibitor of apoptosis repeat-containing 5，BIRC 5，又称生存素）是凋亡抑制蛋白（inhibitor of apoptosis protein，IAP）家族的一员，在肿瘤的发生、发展中起重要作用。最近，在BIRC 5的启动子，-31 C/G（rs 9904341）的多态性，显示影响BIRC 5的表达。我们在中国南方广西省的病例对照人群中研究了-31 C/G是否与鼻咽癌（NPC）的发病风险相关，该人群包括855例NPC患者和1036例对照。该多态性通过TaqMan分析进行基因分型。Logistic回归分析鼻咽癌的发生、发展与遗传因素的关系。我们观察到与CC基因型相关的NPC发生率与包含G等位基因的基因型（CG + GG基因型）相比在统计学上显著增加（比值比[OR]，1.40; 95%可信区间[CI]，1.13-1.73; P = 0.0020）。 然而，未观察到-31 C/G与NPC的严重程度（根据肿瘤淋巴结转移分期系统测量）的显著相关性。BIRC 5基因启动子区-31 C/G多态性可能与中国人鼻咽癌易感性有关。
Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5, also called as survivin) is a member of the inhibitor of apoptosis protein (IAP) family, which plays an important role in the occurrence and progression of cancer. Recently, a polymorphism in the promoter of BIRC5, -31C/G (rs9904341), was shown to influence BIRC5 expression. We examined whether the -31C/G was related to the risk of developing nasopharyngeal carcinoma (NPC) in a case-control population from Guangxi province in southern China, which consists of 855 patients with NPC and 1036 controls. This polymorphism was genotyped by TaqMan assay. The genetic associations with the occurrence and progression of NPC were estimated by logistic regression. We observed a statistically significant increased occurrence of NPC associated with the CC genotype (odds ratio [OR], 1.40; 95% confidence interval [CI], 1.13–1.73; P = 0.0020) compared with the genotypes containing G allele (CG + GG genotype). However, no significant association was observed for the -31C/G with the severity of NPC (as measured by tumor-node-metastasis staging system). Our findings suggest that the functional polymorphism -31C/G in the promoter of BIRC5 gene may play a role in mediating the susceptibility to NPC among Chinese.
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影响因子：
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作者：
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